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    lft2 lefty2 [ Danio rerio (zebrafish) ]

    Gene ID: 30146, updated on 4-Jan-2025

    Summary

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    Official Symbol
    lft2provided by ZNC
    Official Full Name
    lefty2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990630-11
    See related
    Ensembl:ENSDARG00000044059 AllianceGenome:ZFIN:ZDB-GENE-990630-11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    atv2; cb720; fe38b03; wu:fe38b03
    Summary
    Predicted to enable cytokine activity. Acts upstream of or within heart field specification and mesoderm development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastodisc; cardiovascular system; central nervous system; hypoblast; and mesoderm. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human LEFTY2 (left-right determination factor 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See lft2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (8308182..8312891, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (8151004..8155713, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:ch211-236p5.2 Neighboring gene si:ch211-236p5.3 Neighboring gene CDC42 binding protein kinase alpha (DMPK-like) a Neighboring gene frizzled class receptor 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling. Agathon A, et al. Genesis, 2001 Jul. PMID 11477702
    2. Mutations in CCDC11, which encodes a coiled-coil containing ciliary protein, causes situs inversus due to dysmotility of monocilia in the left-right organizer. Narasimhan V, et al. Hum Mutat, 2015 Mar. PMID 25504577
    3. Lefty antagonism of Squint is essential for normal gastrulation. Feldman B, et al. Curr Biol, 2002 Dec 23. PMID 12498688
    4. Flounder and fugu have a single lefty gene that covers the functions of lefty1 and lefty2 of zebrafish during L-R patterning. Hashimoto H, et al. Gene, 2007 Jan 31. PMID 17084042
    5. Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species. He X, et al. Nucleic Acids Res, 2020 Jun 4. PMID 32232370, Free PMC Article

    See all (160) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.
      Title: Nodal patterning without Lefty inhibitory feedback is functional but fragile.
    2. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
      Title: Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.
    3. study reports that microRNA-430 (miR-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta Nodal antagonist lefty
      Title: Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.
    4. we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 transcription
      Title: Lefty antagonism of Squint is essential for normal gastrulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart field specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lefty2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130961.1 → NP_571036.1  lefty2 precursor

      See identical proteins and their annotated locations for NP_571036.1

      Status: PROVISIONAL

      Source sequence(s)
      AF132445
      UniProtKB/TrEMBL
      Q9W6I7
      Related
      ENSDARP00000064677.5, ENSDART00000064678.6
      Conserved Domains (2) summary
      pfam00688
      Location:15 → 204
      TGFb_propeptide; TGF-beta propeptide
      cd13758
      Location:267 → 354
      TGF_beta_LEFTY1_2; transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      8308182..8312891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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