grnb granulin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grnbprovided by ZNC
Official Full Name: granulin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7393
See related: Ensembl:ENSDARG00000025081 AllianceGenome:ZFIN:ZDB-GENE-030131-7393
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj14b08; wu:fj14b08; zgc:111858
Summary: Acts upstream of or within axon extension. Predicted to be active in extracellular region. Is expressed in several structures, including central nervous system; gut; immature eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (36339239..36364786)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (36451201..36476504)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon.
Title: Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
Title: Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology.
A progranulin mutation located within the signal sequence (PGRN A9D) results in cytoplasmic missorting with extremely low expression.
Title: Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.

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General gene information

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Markers

fj14b08.x1 (e-PCR)
- UniSTS:188441

z9127 (e-PCR), detects polymorphism
- UniSTS:204992

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of oligodendrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: granulin b

Names: progranulin-b; zfPGRN-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212738.1 → NP_997903.1 granulin b precursor

See identical proteins and their annotated locations for NP_997903.1

Status: PROVISIONAL

Source sequence(s)

AY289606

UniProtKB/TrEMBL

Q7T3M4

Related

ENSDARP00000096463.3, ENSDART00000105686.6

Conserved Domains (2) summary

smart00277
Location:594 → 644

GRAN; Granulin

pfam00396
Location:440 → 481

Granulin; Granulin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

36339239..36364786

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470114.2 → XP_021325789.1 granulin b isoform X1

UniProtKB/TrEMBL

A0A8M9PLL6, F1R6I2

Conserved Domains (2) summary

smart00277
Location:594 → 644

GRAN; Granulin

pfam00396
Location:440 → 481

Granulin