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    rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 [ Danio rerio (zebrafish) ]

    Gene ID: 335032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rapgef6provided by ZNC
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6972
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-6972
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa12b02
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within proteolysis and small GTPase-mediated signal transduction. Predicted to be located in cytoplasm and membrane. Predicted to be active in apical plasma membrane and endocytic vesicle. Orthologous to human RAPGEF6 (Rap guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See rapgef6 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (45043418..45073740, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (45019098..45049600, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 4 Neighboring gene ring finger protein 121 Neighboring gene follistatin-like 4 Neighboring gene si:ch73-269m14.2 Neighboring gene voltage-dependent anion channel 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      45043418..45073740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353005.2 → XP_017208494.2  rap guanine nucleotide exchange factor 6

      UniProtKB/TrEMBL
      A0A8M6Z3X1
      Conserved Domains (6) summary
      smart00100
      Location:290 → 405
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00147
      Location:866 → 1102
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:421 → 534
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00992
      Location:538 → 618
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:49 → 154
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:759 → 843
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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