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    sin3b SIN3 transcription regulator family member B [ Danio rerio (zebrafish) ]

    Gene ID: 560837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sin3bprovided by ZNC
    Official Full Name
    SIN3 transcription regulator family member Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8264
    See related
    Ensembl:ENSDARG00000062472 AllianceGenome:ZFIN:ZDB-GENE-030131-8264
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj63d08; wu:fj63d08; si:dkey-6n6.6
    Summary
    Predicted to enable transcription corepressor activity. Acts upstream of or within ossification involved in bone maturation and swimming behavior. Predicted to be located in chromatin. Predicted to be part of Sin3-type complex. Orthologous to human SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sin3b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (14211746..14239023, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (14174041..14201318, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene DEF6 guanine nucleotide exchange factor a Neighboring gene xenotropic and polytropic retrovirus receptor 1a Neighboring gene acyl-CoA binding domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish sin3b mutants are viable but have size, skeletal, and locomotor defects. Moravec CE, et al. Dev Dyn, 2017 Nov. PMID 28850761, Free PMC Article
    2. Zebrafish rest regulates developmental gene expression but not neurogenesis. Kok FO, et al. Development, 2012 Oct. PMID 22951640, Free PMC Article
    3. Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Safian D, et al. Gen Comp Endocrinol, 2019 Dec 1. PMID 31415728
    4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sin3b is not essential in zebrafish
      Title: Zebrafish sin3b mutants are viable but have size, skeletal, and locomotor defects.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ossification involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within swimming behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    paired amphipathic helix protein Sin3b
    Names
    SIN3 homolog B, transcription regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044945.1 → NP_001038410.1  paired amphipathic helix protein Sin3b

      See identical proteins and their annotated locations for NP_001038410.1

      Status: PROVISIONAL

      Source sequence(s)
      BX004884
      UniProtKB/TrEMBL
      B7ZV87, Q1LYM8
      Related
      ENSDARP00000084804.5, ENSDART00000090371.6
      Conserved Domains (4) summary
      COG5602
      Location:36 → 1135
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:58 → 101
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:439 → 533
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:811 → 1108
      Sin3a_C; C-terminal domain of Sin3a protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      14211746..14239023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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