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    dnajb11 DnaJ heat shock protein family (Hsp40) member B11 [ Danio rerio (zebrafish) ]

    Gene ID: 386709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnajb11provided by ZNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B11provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031113-9
    See related
    Ensembl:ENSDARG00000015088 AllianceGenome:ZFIN:ZDB-GENE-031113-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb954
    Summary
    Predicted to enable misfolded protein binding activity and unfolded protein binding activity. Predicted to be involved in protein maturation. Predicted to act upstream of or within protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including axial mesoderm; blood vessel; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dnajb11 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (32641028..32648692, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (32830282..32837952, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene phospholipase C like 1 Neighboring gene SATB homeobox 2 Neighboring gene RAB, member of RAS oncogene family-like 3 Neighboring gene granzyme 3, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mother-Specific Signature in the Maternal Transcriptome Composition of Mature, Unfertilized Zebrafish Eggs. Rauwerda H, et al. PLoS One, 2016. PMID 26799215, Free PMC Article
    2. Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1. Kashyap B, et al. Reprod Toxicol, 2014 Jan. PMID 24355176, Free PMC Article
    3. RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. Yang D, et al. BMC Genomics, 2012 Jul 17. PMID 22805612, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 11
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198821.1 → NP_942116.1  dnaJ homolog subfamily B member 11 precursor

      See identical proteins and their annotated locations for NP_942116.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044559
      UniProtKB/TrEMBL
      Q803A9
      Conserved Domains (3) summary
      cd10747
      Location:134 → 331
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:24 → 346
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:27 → 89
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      32641028..32648692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167678.5 → XP_005167735.1  dnaJ homolog subfamily B member 11 isoform X1

      See identical proteins and their annotated locations for XP_005167735.1

      UniProtKB/TrEMBL
      A9JRS7, Q6NYZ0
      Related
      ENSDARP00000107433.2, ENSDART00000123374.4
      Conserved Domains (3) summary
      cd10747
      Location:134 → 331
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:24 → 346
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:27 → 89
      DnaJ; DnaJ domain

    2. XM_021478626.2 → XP_021334301.1  dnaJ homolog subfamily B member 11 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QFA3
      Conserved Domains (1) summary
      COG0484
      Location:1 → 324
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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