cebp1 CCAAT/enhancer binding protein (C/EBP) 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cebp1provided by ZNC
Official Full Name: CCAAT/enhancer binding protein (C/EBP) 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010611-1
See related: Ensembl:ENSDARG00000101096 AllianceGenome:ZFIN:ZDB-GENE-010611-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: c/ebp1; cb1070; unp1282
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within myeloid cell differentiation; regulation of gene expression; and regulation of neutrophil differentiation. Predicted to be located in nucleus. Is expressed in several structures, including ectoderm; hematopoietic cell; hematopoietic system; neutrophilic promyelocyte; and segmental plate. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (40820755..40830494, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (41120961..41130700, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cebp1 and Cebpbeta transcriptional axis controls eosinophilopoiesis in zebrafish.
Title: Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish.
studies show that merestinib effectively blocks eIF4E phosphorylation in AML cells and suppresses primitive leukemic progenitors from AML patients in vitro and in an AML xenograft model in vivo.
Title: c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish.
Knockdown of the c=ebp1 gene did not ablate initial macrophage or granulocyte development, but resulted in loss of expression of the secondary granule gene lys C.
Title: Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neutrophil differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCAAT/enhancer binding protein (C/EBP) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131837.1 → NP_571912.1 CCAAT/enhancer binding protein (C/EBP) 1

See identical proteins and their annotated locations for NP_571912.1

Status: PROVISIONAL

Source sequence(s)

AF306857

UniProtKB/TrEMBL

Q90ZW4

Related

ENSDARP00000142714.1, ENSDART00000161766.2

Conserved Domains (1) summary

cd14693
Location:96 → 155

bZIP_CEBP; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein (CEBP) and similar proteins: a DNA-binding and dimerization domain