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    pls1 plastin 1 (I isoform) [ Danio rerio (zebrafish) ]

    Gene ID: 334273, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pls1provided by ZNC
    Official Full Name
    plastin 1 (I isoform)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6205
    See related
    Ensembl:ENSDARG00000039272 AllianceGenome:ZFIN:ZDB-GENE-030131-6205
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63494; wu:fi38g03
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Is expressed in macrophage; otic vesicle; pronephros; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See pls1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (8060775..8112826, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (8262770..8314009, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene eph receptor B3a Neighboring gene procollagen C-endopeptidase enhancer 2a Neighboring gene carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2a Neighboring gene uncharacterized LOC103909784 Neighboring gene uncharacterized LOC137487291

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel PLS1 c.981+1G>A variant causes autosomal-dominant hereditary hearing loss in a family. Xu L, et al. Clin Genet, 2023 Apr. PMID 36537221
    2. Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1). Kell MJ, et al. PLoS One, 2018. PMID 29293625, Free PMC Article
    3. Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. Mathias JR, et al. J Cell Sci, 2007 Oct 1. PMID 17881499
    4. Ccdc103 promotes myeloid cell proliferation and migration independent of motile cilia. Falkenberg LG, et al. Dis Model Mech, 2021 May 1. PMID 34028558, Free PMC Article
    5. Zebrafish as a model for myelopoiesis during embryogenesis. Berman JN, et al. Exp Hematol, 2005 Sep. PMID 16140147

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plastin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199881.1 → NP_956175.1  plastin-1

      See identical proteins and their annotated locations for NP_956175.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063742
      UniProtKB/TrEMBL
      Q6P406
      Conserved Domains (4) summary
      smart00033
      Location:397 → 500
      CH; Calponin homology domain
      COG5069
      Location:4 → 619
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:15 → 78
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00307
      Location:122 → 231
      CH; Calponin homology (CH) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      8060775..8112826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479039.2 → XP_021334714.1  plastin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QBL9, F1QCE2
      Related
      ENSDARP00000109993.3, ENSDART00000123103.4
      Conserved Domains (1) summary
      COG5069
      Location:35 → 656
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

    2. XM_021479043.2 → XP_021334718.1  plastin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q5A8, A5PM88, F1Q9Y7
      Conserved Domains (1) summary
      COG5069
      Location:4 → 619
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

    3. XM_068223101.1 → XP_068079202.1  plastin-1 isoform X2

      Related
      ENSDARP00000113948.2, ENSDART00000131955.4
    Nucleotide Protein Strain
    Heading Accession and Version

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