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    csnk2a2a casein kinase 2, alpha prime polypeptide a [ Danio rerio (zebrafish) ]

    Gene ID: 30488, updated on 2-Nov-2024

    Summary

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    Official Symbol
    csnk2a2aprovided by ZNC
    Official Full Name
    casein kinase 2, alpha prime polypeptide aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-28
    See related
    Ensembl:ENSDARG00000012818 AllianceGenome:ZFIN:ZDB-GENE-990415-28
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ck2a2; ck2a2a; wu:fi09h12
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in DNA damage response and regulation of chromosome separation. Predicted to act upstream of or within protein phosphorylation. Predicted to be part of protein kinase CK2 complex. Predicted to be active in cytosol and nucleus. Orthologous to human CSNK2A2 (casein kinase 2 alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See csnk2a2a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (56751746..56766967, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (56450335..56465556, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene NAD(P)H dehydrogenase, quinone 1 Neighboring gene kiaa0895l Neighboring gene zinc finger protein 319 Neighboring gene junctophilin 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional analyses of aspolin, a fish-specific protein extremely rich in aspartic acid. Kinoshita S, et al. Mar Biotechnol (NY), 2011 Jun. PMID 20878432
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chromosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase 2, alpha prime polypeptide a
    Names
    casein kinase 2 alpha 2
    casein kinase 2 alpha 2a
    ck2 alpha'
    etID309898.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131240.1 → NP_571315.1  casein kinase 2, alpha prime polypeptide a

      See identical proteins and their annotated locations for NP_571315.1

      Status: PROVISIONAL

      Source sequence(s)
      X99964
      UniProtKB/TrEMBL
      Q90457
      Related
      ENSDARP00000027027.6, ENSDART00000020967.7
      Conserved Domains (2) summary
      cd14132
      Location:21 → 325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
      pfam00069
      Location:39 → 324
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      56751746..56766967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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