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    anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A [ Danio rerio (zebrafish) ]

    Gene ID: 335907, updated on 2-Nov-2024

    Summary

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    Official Symbol
    anp32aprovided by ZNC
    Official Full Name
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7850
    See related
    Ensembl:ENSDARG00000006487 AllianceGenome:ZFIN:ZDB-GENE-030131-7850
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55516; wu:fj36e08
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in nucleocytoplasmic transport and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to several human genes including ANP32A (acidic nuclear phosphoprotein 32 family member A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See anp32a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (33345627..33350002, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (33074477..33078852, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496180 Neighboring gene coronin, actin binding protein, 2Ba Neighboring gene glucuronic acid epimerase b Neighboring gene progestin and adipoQ receptor family member Vb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Anp32a Promotes Neuronal Regeneration after Spinal Cord Injury of Zebrafish Embryos. Lee HC, et al. Int J Mol Sci, 2022 Dec 14. PMID 36555564, Free PMC Article
    2. The Anp32 family of proteins containing leucine-rich repeats. Matilla A, et al. Cerebellum, 2005. PMID 15895553
    3. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Ayobahan SU, et al. Sci Rep, 2019 Apr 29. PMID 31036921, Free PMC Article
    4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    5. High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Niksirat H, et al. J Proteome Res, 2021 Aug 6. PMID 34185526

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acidic leucine-rich nuclear phosphoprotein 32 family member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199986.1 → NP_956280.1  acidic leucine-rich nuclear phosphoprotein 32 family member A

      See identical proteins and their annotated locations for NP_956280.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048047
      UniProtKB/Swiss-Prot
      Q7ZUP0
      UniProtKB/TrEMBL
      B2GSB4
      Related
      ENSDARP00000022360.6, ENSDART00000008785.9
      Conserved Domains (3) summary
      smart00446
      Location:128 → 146
      LRRcap; occurring C-terminal to leucine-rich repeats
      sd00033
      Location:90 → 114
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:88 → 130
      LRR_4; Leucine Rich repeats (2 copies)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      33345627..33350002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUP0.1 GenPept UniProtKB/Swiss-Prot:Q7ZUP0

    Gene LinkOut

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