scinla scinderin like a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scinlaprovided by ZNC
Official Full Name: scinderin like aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2005
See related: Ensembl:ENSDARG00000102415 AllianceGenome:ZFIN:ZDB-GENE-030131-2005
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gsn; cb499; gsnl1; fb94b12; fc04g09; sb:cb499; wu:fc04g09
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within brain development; dorsal/ventral pattern formation; and eye development. Predicted to be active in actin cytoskeleton; cytoplasm; and extracellular space. Is expressed in several structures, including corneal epithelial cell; median fin; nervous system; periderm; and solid lens vesicle. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (24090950..24103531, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (23991141..24003722, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that scinla and scinlb have different expression patterns and developmental roles during zebrafish development.
Title: Differential expression patterns and developmental roles of duplicated scinderin-like genes in zebrafish.
Data suggest that scinla and scinlb are diverged paralogs of the vertebrate scinderin gene, and show that scinla encodes the zebrafish corneal crystallin previously called C/L-gelsolin.
Title: Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin.
Unique enhancers for corneal epithelium and the annular ligament found at 3.7-kb upstream from ATG; proximal promoter located 1.6-kb upstream from the ATG.
Title: Transgenic analysis of the anterior eye-specific enhancers of the zebrafish gelsolin-like 1 (gsnl1) gene.

Submit: New GeneRIF Correction

General gene information

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Markers

fb94b12.x1 (e-PCR)
- UniSTS:203551

AI629201 (e-PCR)
- UniSTS:206125

fj31d12.y1 (e-PCR)
- UniSTS:199040

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: scinderin like a

Names: C/L gelsolin; gelsolin (amyloidosis, Finnish type); gelsolin, like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178131.3 → NP_835232.2 scinderin like a

See identical proteins and their annotated locations for NP_835232.2

Status: PROVISIONAL

Source sequence(s)

BC134865

UniProtKB/TrEMBL

A0JMJ1

Related

ENSDARP00000138611.1, ENSDART00000164915.2

Conserved Domains (6) summary

cd11288
Location:506 → 594

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:131 → 212

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:7 → 115

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:608 → 704

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:239 → 339

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:383 → 483

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins