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    rab25a RAB25, member RAS oncogene family a [ Danio rerio (zebrafish) ]

    Gene ID: 494098, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rab25aprovided by ZNC
    Official Full Name
    RAB25, member RAS oncogene family aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-69
    See related
    Ensembl:ENSDARG00000058800 AllianceGenome:ZFIN:ZDB-GENE-041212-69
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rab25; zgc:101648; si:dkeyp-84f11.7
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cortical actin cytoskeleton organization; regulation of cytokinesis; and regulation of endocytic recycling. Predicted to be active in Golgi apparatus and recycling endosome. Is expressed in EVL. Orthologous to human RAB25 (RAB25, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See rab25a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7413606..7420863, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7494681..7501938, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene oxidation resistance 1b Neighboring gene NAD(P)HX epimerase Neighboring gene splicing factor 3b, subunit 4 Neighboring gene GA binding protein transcription factor subunit beta 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium. Willoughby PM, et al. Elife, 2021 Mar 23. PMID 33755014, Free PMC Article
    2. Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration. Piloto S, et al. Development, 2010 Jun. PMID 20463035, Free PMC Article
    3. The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Wei S, et al. Cell Res, 2017 Feb. PMID 27910850, Free PMC Article
    4. A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Melvin VS, et al. Dev Dyn, 2013 Jul. PMID 23559552, Free PMC Article
    5. Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Xu H, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2021 Sep. PMID 34111665

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium.
      Title: The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-25a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008641.2 → NP_001008641.2  ras-related protein Rab-25a

      See identical proteins and their annotated locations for NP_001008641.2

      Status: VALIDATED

      Source sequence(s)
      EH456340, FP085396
      UniProtKB/TrEMBL
      A0A8M1N3T9, Q1LVA5
      Related
      ENSDARP00000076180.2, ENSDART00000081741.4
      Conserved Domains (2) summary
      smart00175
      Location:11 → 174
      RAB; Rab subfamily of small GTPases
      cd01868
      Location:9 → 172
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      7413606..7420863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215122.1 → XP_068071223.1  ras-related protein Rab-25a isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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