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    hectd2 HECT domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 562999, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hectd2provided by ZNC
    Official Full Name
    HECT domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100405-3
    See related
    Ensembl:ENSDARG00000061194 AllianceGenome:ZFIN:ZDB-GENE-100405-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within protein polyubiquitination. Orthologous to human HECTD2 (HECT domain E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hectd2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (16330300..16380612, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (16283533..16332292, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 2b Neighboring gene MAGUK p55 scaffold protein 3b Neighboring gene protein phosphatase 1, regulatory subunit 3Cb Neighboring gene polycomb group ring finger 5b Neighboring gene ankyrin repeat domain 1b (cardiac muscle) Neighboring gene ribonuclease P/MRP 30 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. Boskovic S, et al. PLoS One, 2018. PMID 30252882, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HECTD2
    XP_009304826.1
    XP_691455.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      16330300..16380612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_686363.9 → XP_691455.5  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

      UniProtKB/TrEMBL
      A0A8N7TB81
      Conserved Domains (2) summary
      smart00119
      Location:419 → 752
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:396 → 753
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_009306551.4 → XP_009304826.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B7B1, E7EYX5
      Related
      ENSDARP00000081418.4, ENSDART00000086984.8
      Conserved Domains (2) summary
      smart00119
      Location:420 → 753
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:397 → 754
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein
    Heading Accession and Version

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