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    Vdac3 voltage-dependent anion channel 3 [ Mus musculus (house mouse) ]

    Gene ID: 22335, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Vdac3provided by MGI
    Official Full Name
    voltage-dependent anion channel 3provided by MGI
    Primary source
    MGI:MGI:106922
    See related
    Ensembl:ENSMUSG00000008892 AllianceGenome:MGI:106922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable voltage-gated monoatomic anion channel activity. Involved in sperm mitochondrial sheath assembly. Acts upstream of or within behavioral fear response; learning; and neuron-neuron synaptic transmission. Located in mitochondrion. Orthologous to human VDAC3 (voltage dependent anion channel 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 68.2), testis adult (RPKM 53.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vdac3 in Genome Data Viewer
    Location:
    8 A2; 8 11.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23067091..23083829, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22577075..22593813, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39140 Neighboring gene small integral membrane protein 19 Neighboring gene STARR-positive B cell enhancer ABC_E9722 Neighboring gene solute carrier family 20, member 2 Neighboring gene STARR-seq mESC enhancer starr_20908 Neighboring gene predicted gene, 30086 Neighboring gene predicted gene, 30135

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. VDAC3 has differing mitochondrial functions in two types of striated muscles. Anflous-Pharayra K, et al. Biochim Biophys Acta, 2011 Jan. PMID 20875390, Free PMC Article
    2. Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport. Zou L, et al. J Biol Chem, 2018 Feb 2. PMID 29180450, Free PMC Article
    3. A novel isoform of the mitochondrial outer membrane protein VDAC3 via alternative splicing of a 3-base exon. Functional characteristics and subcellular localization. Sampson MJ, et al. J Biol Chem, 1998 Nov 13. PMID 9804816
    4. Each mammalian mitochondrial outer membrane porin protein is dispensable: effects on cellular respiration. Wu S, et al. Biochim Biophys Acta, 1999 Oct 13. PMID 10525161
    5. Immotile sperm and infertility in mice lacking mitochondrial voltage-dependent anion channel type 3. Sampson MJ, et al. J Biol Chem, 2001 Oct 19. PMID 11507092

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that knocking out mitochondrial VDAC3 increases ROS, alters renal sodium transport, and leads to hypertension.
      Title: Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport.
    2. Bcl-xL interacts functionally with VDAC1 and -3 but not VDAC2.
      Title: An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.
    3. Abnormal regulation of VDACs negatively affected sperm function. Thus, VDACs may be key regulators of the fertilization ability of spermatozoa.
      Title: Voltage-dependent anion channels are a key factor of male fertility.
    4. (n VDAC3 deficient mice the defect is restricted to the heart and only to complex IV.
      Title: VDAC3 has differing mitochondrial functions in two types of striated muscles.
    5. Bid catalyzes MAC formation in isolated mitochondria containing Bax and/or Bak with a time course of minutes and does not require VDAC1 or VDAC3.
      Title: Assembly of the mitochondrial apoptosis-induced channel, MAC.
    6. Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death.
      Title: Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102096

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm mitochondrial sheath assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent anion-selective channel protein 3
    Names
    VDAC-3
    channel protein VDAC3
    mVDAC3
    mitochondrial outer membrane protein
    outer mitochondrial membrane protein porin 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198998.1 → NP_001185927.1  voltage-dependent anion-selective channel protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001185927.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK002296, AK146957, BY103517
      UniProtKB/TrEMBL
      Q3TTN3, Q5EBQ0
      Conserved Domains (1) summary
      cd07306
      Location:5 → 283
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    2. NM_011696.2 → NP_035826.1  voltage-dependent anion-selective channel protein 3 isoform 2

      See identical proteins and their annotated locations for NP_035826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' coding region, compared to variant 1, and encodes an isoform (2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK002296, AK150741, BY103517
      Consensus CDS
      CCDS22179.1
      UniProtKB/Swiss-Prot
      Q60931, Q8BNG2
      UniProtKB/TrEMBL
      Q3TTN3, Q3TX38
      Related
      ENSMUSP00000009036.4, ENSMUST00000009036.11
      Conserved Domains (1) summary
      cd07306
      Location:5 → 282
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      23067091..23083829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60931.1 GenPept UniProtKB/Swiss-Prot:Q60931

    Gene LinkOut

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