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    DPP9 dipeptidyl peptidase 9 [ Homo sapiens (human) ]

    Gene ID: 91039, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DPP9provided by HGNC
    Official Full Name
    dipeptidyl peptidase 9provided by HGNC
    Primary source
    HGNC:HGNC:18648
    See related
    Ensembl:ENSG00000142002 MIM:608258; AllianceGenome:HGNC:18648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DP9; DPLP9; DPRP2; HATIS; DPP IX; DPRP-2; IMD111
    Summary
    This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Ubiquitous expression in spleen (RPKM 7.8), appendix (RPKM 7.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DPP9 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4675227..4723842, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4659400..4708159, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4675239..4723854, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4639529-4640528 Neighboring gene TNF alpha induced protein 8 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4660681-4661180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4661482-4662252 Neighboring gene myeloid derived growth factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4675983-4676943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4679601-4680102 Neighboring gene DPP9 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:4694063-4695262 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:4703720-4704919 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:4713085-4714284 Neighboring gene uncharacterized LOC105372250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9904 Neighboring gene tRNA-Gly (anticodon TCC) 1-1 Neighboring gene tRNA-Val (anticodon CAC) 3-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Contribution of upregulated dipeptidyl peptidase 9 (DPP9) in promoting tumoregenicity, metastasis and the prediction of poor prognosis in non-small cell lung cancer (NSCLC). Tang Z, et al. Int J Cancer, 2017 Apr 1. PMID 27943262, Free PMC Article
    2. Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. Olsen C, et al. Gene, 2002 Oct 16. PMID 12459266
    3. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. Ajami K, et al. Biochim Biophys Acta, 2004 Jul 13. PMID 15245913
    4. Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV. Bjelke JR, et al. Biochem J, 2006 Jun 1. PMID 16475979, Free PMC Article
    5. Association study between adolescent idiopathic scoliosis and the DPP9 gene which is located in the candidate region identified by linkage analysis. Qiu XS, et al. Postgrad Med J, 2008 Sep. PMID 18940951

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy in liver cancer cells.
      Title: DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy in liver cancer cells.
    2. Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer.
      Title: Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer.
    3. DPP8/9 inhibition attenuates the TGF-beta1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.
      Title: DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.
    4. DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
      Title: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
    5. Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a de novo mutation in DPP9.
      Title: Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a de novo mutation in DPP9.
    6. Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain.
      Title: Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain.
    7. CCR2 and DPP9 expression in the peripheral blood of COVID-19 patients: Influences of the disease severity and gender.
      Title: CCR2 and DPP9 expression in the peripheral blood of COVID-19 patients: Influences of the disease severity and gender.
    8. Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.
      Title: Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.
    9. DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
      Title: DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
    10. Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
      Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hatipoglu immunodeficiency syndrome
    MedGen: C5830439 OMIM: 620331 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16073, DKFZp762F117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidyl-peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_negative_effect pyroptotic inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 9
    Names
    dipeptidyl peptidase IV-related protein-2
    dipeptidyl peptidase IX
    dipeptidyl peptidase-like protein 9
    NP_001352916.1
    NP_001371540.1
    NP_001371541.1
    NP_001371542.1
    NP_001371543.1
    NP_001371544.1
    NP_001371545.1
    NP_001371546.1
    NP_001371547.1
    NP_001371548.1
    NP_001371549.1
    NP_001371550.1
    NP_001371551.1
    NP_001371552.1
    NP_001371553.1
    NP_001371554.1
    NP_001371555.1
    NP_001371556.1
    NP_001371557.1
    NP_001371558.1
    NP_001371559.1
    NP_001371560.1
    NP_001371561.1
    NP_001371562.1
    NP_001371563.1
    NP_001371564.1
    NP_001371565.1
    NP_001371566.1
    NP_001371567.1
    NP_631898.3
    XP_011526707.1
    XP_047295608.1
    XP_047295609.1
    XP_047295610.1
    XP_054178532.1
    XP_054178533.1
    XP_054178534.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365987.2 → NP_001352916.1  dipeptidyl peptidase 9 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 9, encodes isoform 2.
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS92492.1
      UniProtKB/TrEMBL
      M0R2A8
      Related
      ENSP00000472430.1, ENST00000597849.5
      Conserved Domains (1) summary
      pfam00930
      Location:175 → 495
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. NM_001384611.1 → NP_001371540.1  dipeptidyl peptidase 9 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS45928.1
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:691 → 892
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    3. NM_001384612.1 → NP_001371541.1  dipeptidyl peptidase 9 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS45928.1
      UniProtKB/TrEMBL
      A0A8V8TR99
      Related
      ENSP00000471629.2, ENST00000601130.6
      Conserved Domains (2) summary
      pfam00326
      Location:691 → 892
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    4. NM_001384613.1 → NP_001371542.1  dipeptidyl peptidase 9 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS45928.1
      UniProtKB/TrEMBL
      A0A8V8TR99
      Related
      ENSP00000472549.2, ENST00000600621.6
      Conserved Domains (2) summary
      pfam00326
      Location:691 → 892
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    5. NM_001384614.1 → NP_001371543.1  dipeptidyl peptidase 9 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS45928.1
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:691 → 892
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    6. NM_001384615.1 → NP_001371544.1  dipeptidyl peptidase 9 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS45928.1
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:691 → 892
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    7. NM_001384616.1 → NP_001371545.1  dipeptidyl peptidase 9 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS92492.1
      UniProtKB/TrEMBL
      M0R2A8
      Conserved Domains (1) summary
      pfam00930
      Location:175 → 495
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    8. NM_001384617.1 → NP_001371546.1  dipeptidyl peptidase 9 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:689 → 890
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    9. NM_001384618.1 → NP_001371547.1  dipeptidyl peptidase 9 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:682 → 883
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    10. NM_001384619.1 → NP_001371548.1  dipeptidyl peptidase 9 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:680 → 881
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 588
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    11. NM_001384620.1 → NP_001371549.1  dipeptidyl peptidase 9 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 14, encodes isoform 6.
      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:678 → 879
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 586
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    12. NM_001384621.1 → NP_001371550.1  dipeptidyl peptidase 9 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variant 13, encodes isoform 6.
      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:678 → 879
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 586
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    13. NM_001384622.1 → NP_001371551.1  dipeptidyl peptidase 9 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Related
      ENSP00000472224.1, ENST00000594671.5
      Conserved Domains (2) summary
      COG1506
      Location:533 → 864
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    14. NM_001384623.1 → NP_001371552.1  dipeptidyl peptidase 9 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 17-20, encodes isoform 7.
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS92491.1
      UniProtKB/Swiss-Prot
      O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:662 → 863
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:146 → 570
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    15. NM_001384624.1 → NP_001371553.1  dipeptidyl peptidase 9 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 16 and 18-20, encodes isoform 7.
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS92491.1
      UniProtKB/Swiss-Prot
      O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:662 → 863
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:146 → 570
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    16. NM_001384625.1 → NP_001371554.1  dipeptidyl peptidase 9 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 16, 17,19, and 20, encodes isoform 7.
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS92491.1
      UniProtKB/Swiss-Prot
      O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
      UniProtKB/TrEMBL
      A0A8V8TR99
      Related
      ENSP00000469603.1, ENST00000598800.5
      Conserved Domains (2) summary
      pfam00326
      Location:662 → 863
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:146 → 570
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    17. NM_001384626.1 → NP_001371555.1  dipeptidyl peptidase 9 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 16-18 and 20, encodes isoform 7.
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS92491.1
      UniProtKB/Swiss-Prot
      O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:662 → 863
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:146 → 570
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    18. NM_001384627.1 → NP_001371556.1  dipeptidyl peptidase 9 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 16-19, encodes isoform 7.
      Source sequence(s)
      AC005594, AC005783
      Consensus CDS
      CCDS92491.1
      UniProtKB/Swiss-Prot
      O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:662 → 863
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:146 → 570
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    19. NM_001384628.1 → NP_001371557.1  dipeptidyl peptidase 9 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variant 22, encodes isoform 8.
      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      COG1506
      Location:533 → 822
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    20. NM_001384629.1 → NP_001371558.1  dipeptidyl peptidase 9 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variant 21, encodes isoform 8.
      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Related
      ENSP00000515244.1, ENST00000703254.1
      Conserved Domains (2) summary
      COG1506
      Location:533 → 822
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    21. NM_001384630.1 → NP_001371559.1  dipeptidyl peptidase 9 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:678 → 843
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    22. NM_001384631.1 → NP_001371560.1  dipeptidyl peptidase 9 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783
      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:611 → 812
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 519
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    23. NM_001384632.1 → NP_001371561.1  dipeptidyl peptidase 9 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variant 26, encodes isoform 11.
      Source sequence(s)
      AC005594, AC005783
      Conserved Domains (1) summary
      pfam00930
      Location:146 → 466
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    24. NM_001384633.1 → NP_001371562.1  dipeptidyl peptidase 9 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variant 25, encodes isoform 11.
      Source sequence(s)
      AC005594, AC005783
      Conserved Domains (1) summary
      pfam00930
      Location:146 → 466
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    25. NM_001384634.1 → NP_001371563.1  dipeptidyl peptidase 9 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783
      Conserved Domains (1) summary
      pfam00930
      Location:175 → 423
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    26. NM_001384635.1 → NP_001371564.1  dipeptidyl peptidase 9 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783
      Conserved Domains (1) summary
      pfam00930
      Location:175 → 415
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    27. NM_001384636.1 → NP_001371565.1  dipeptidyl peptidase 9 isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform 14.
      Source sequence(s)
      AC005594, AC005783
      Conserved Domains (1) summary
      pfam00930
      Location:175 → 391
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    28. NM_001384637.1 → NP_001371566.1  dipeptidyl peptidase 9 isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform 14.
      Source sequence(s)
      AC005594, AC005783
      Related
      ENST00000601764.5
      Conserved Domains (1) summary
      pfam00930
      Location:175 → 391
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    29. NM_001384638.1 → NP_001371567.1  dipeptidyl peptidase 9 isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform 14.
      Source sequence(s)
      AC005594, AC005783
      Conserved Domains (1) summary
      pfam00930
      Location:175 → 391
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    30. NM_139159.5 → NP_631898.3  dipeptidyl peptidase 9 isoform 1

      See identical proteins and their annotated locations for NP_631898.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 4-8 all encode the same isoform (1).
      Source sequence(s)
      AC005594, BC000970, BC037948, DB105598, DQ417928
      Consensus CDS
      CCDS45928.1
      UniProtKB/TrEMBL
      A0A8V8TR99
      Related
      ENSP00000262960.8, ENST00000262960.14
      Conserved Domains (2) summary
      pfam00326
      Location:691 → 892
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:175 → 599
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RNA

    1. NR_158699.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    2. NR_169283.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    3. NR_169284.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    4. NR_169285.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    5. NR_169286.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    6. NR_169287.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    7. NR_169288.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    8. NR_169289.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    9. NR_169290.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    10. NR_169291.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    11. NR_169292.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005594, AC005783

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      4675227..4723842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528405.2 → XP_011526707.1  dipeptidyl peptidase 9 isoform X1

      See identical proteins and their annotated locations for XP_011526707.1

      UniProtKB/TrEMBL
      A0A8V8TR99
      Conserved Domains (2) summary
      pfam00326
      Location:745 → 946
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:229 → 653
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. XM_047439653.1 → XP_047295609.1  dipeptidyl peptidase 9 isoform X3

      UniProtKB/Swiss-Prot
      O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
      UniProtKB/TrEMBL
      A0A8V8TR99
      Related
      ENSP00000515514.1, ENST00000593973.2

    3. XM_047439652.1 → XP_047295608.1  dipeptidyl peptidase 9 isoform X2

      UniProtKB/TrEMBL
      A0A2R8YF65

    4. XM_047439654.1 → XP_047295610.1  dipeptidyl peptidase 9 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      4659400..4708159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322557.1 → XP_054178532.1  dipeptidyl peptidase 9 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TR99

    2. XM_054322558.1 → XP_054178533.1  dipeptidyl peptidase 9 isoform X2

      UniProtKB/TrEMBL
      A0A2R8YF65

    3. XM_054322559.1 → XP_054178534.1  dipeptidyl peptidase 9 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86TI2.3 GenPept UniProtKB/Swiss-Prot:Q86TI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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