Nkg7 natural killer cell group 7 sequence [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nkg7provided by MGI
Official Full Name: natural killer cell group 7 sequenceprovided by MGI
Primary source: MGI:MGI:1931250
See related: Ensembl:ENSMUSG00000004612 AllianceGenome:MGI:1931250
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2500004F03Rik
Summary: Involved in several processes, including CD4-positive, alpha-beta T cell activation; defense response to other organism; and granzyme-mediated programmed cell death signaling pathway. Located in cytolytic granule. Is expressed in ductus deferens; epididymis; esophagus; prostate gland; and thymus primordium. Orthologous to human NKG7 (natural killer cell granule protein 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in spleen adult (RPKM 41.6), mammary gland adult (RPKM 22.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.25 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43086562..43087670)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43437138..43438246)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation.
Title: NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation.
NKG7 Is Required for Optimal Antitumor T-cell Immunity.
Title: NKG7 Is Required for Optimal Antitumor T-cell Immunity.
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
Title: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in CD4-positive, alpha-beta T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in granzyme-mediated programmed cell death signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell mediated cytotoxicity directed against tumor cell target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytolytic granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytolytic granule membrane	ISO Inferred from Sequence Orthology more info
located_in cytolytic granule membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein NKG7

Names: natural killer cell protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.