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    LINC00161 long intergenic non-protein coding RNA 161 [ Homo sapiens (human) ]

    Gene ID: 118421, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00161provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 161provided by HGNC
    Primary source
    HGNC:HGNC:17138
    See related
    Ensembl:ENSG00000226935 AllianceGenome:HGNC:17138
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C21orf100; Linc-USP16; NCRNA00161
    Expression
    Restricted expression toward prostate (RPKM 1.4) See more
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    Genomic context

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    See LINC00161 in Genome Data Viewer
    Location:
    21q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (28539318..28540355)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (26902245..26903282)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (29911640..29912677)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr21:29390498-29390664 Neighboring gene long intergenic non-protein coding RNA 314 Neighboring gene long intergenic non-protein coding RNA 1697 Neighboring gene long intergenic non-protein coding RNA 1695 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:29697851-29698465 Neighboring gene N-6 adenine-specific DNA methyltransferase 1 Neighboring gene uncharacterized LOC124905067 Neighboring gene Sharpr-MPRA regulatory region 7516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18322 Neighboring gene MPRA-validated peak4395 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:30206496-30207695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:30228725-30229226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:30229227-30229726 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr21:30256988-30257547 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr21:30257548-30258106 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression. Sui J, et al. Cell Physiol Biochem, 2017. PMID 29179215
    2. LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism. Pucci P, et al. Epigenomics, 2020 Jul. PMID 32618200
    3. Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma. You LN, et al. Cancer Gene Ther, 2021 Jun. PMID 33414518
    4. Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA-128 and modulating MAPK1. Xu M, et al. Mol Carcinog, 2019 Apr. PMID 30556928
    5. Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. Wang Y, et al. Cancer Lett, 2016 Nov 28. PMID 27609068

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma.
      Title: Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma.
    2. LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.
      Title: LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.
    3. High LINC00161 expression is associated with drug resistance in ovarian cancer.
      Title: Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA-128 and modulating MAPK1.
    4. Linc-USP16 suppressed AKT pathway activation via regulation of PTEN expression in a transcription-independent manner.
      Title: Long Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression.
    5. LINC00161 is an essential regulator in cisplatin-induced apoptosis, and the LINC00161-miR-645-IFIT2 signalling axis plays an important role in reducing osteosarcoma chemoresistance.
      Title: Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Clone Names

    • MGC125397, MGC125398, MGC125399, MGC125400

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026552.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AF165147
      Related
      ENST00000412526.5

    2. NR_026553.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AF165147
      Related
      ENST00000455939.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      28539318..28540355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      26902245..26903282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials