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    DYNLT2 dynein light chain Tctex-type 2 [ Homo sapiens (human) ]

    Gene ID: 6991, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DYNLT2provided by HGNC
    Official Full Name
    dynein light chain Tctex-type 2provided by HGNC
    Primary source
    HGNC:HGNC:11695
    See related
    Ensembl:ENSG00000184786 MIM:186977; AllianceGenome:HGNC:11695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCTE3; oda12; TCTEX2; Tctex4; TCTEX1D3
    Summary
    Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cytosol and sperm flagellum. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 8.5), ovary (RPKM 0.9) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DYNLT2 in Genome Data Viewer
    Location:
    6q27
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (169725091..169751572, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (171079012..171105502, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (170140205..170151668, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 27 Neighboring gene uncharacterized LOC124901471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170040667-170041282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170047131-170048124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25463 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:170056229-170057024 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:170057025-170057820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170061015-170061514 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:170062913-170064112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170068091-170068591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170067590-170068090 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:170067058-170067246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170092723-170093223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:170124719-170125261 Neighboring gene chromosome 6 open reading frame 120 Neighboring gene MPRA-validated peak6328 silencer Neighboring gene PHD finger protein 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170171824-170172324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170172325-170172825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:170183046-170183546 Neighboring gene ER membrane associated RNA degradation Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170200599-170201291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170201292-170201985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170201986-170202678 Neighboring gene long intergenic non-protein coding RNA 242 Neighboring gene long intergenic non-protein coding RNA 574 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:170227060-170227735 Neighboring gene zinc finger protein 227-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. T-complex-associated-testis-expressed 3 (TCTE3) is a novel marker for pancreatobiliary carcinomas. Zhao CL, et al. Hum Pathol, 2017 Dec. PMID 29079176, Free PMC Article
    2. Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array. Teshiba R, et al. Pediatr Surg Int, 2011 Feb. PMID 21085971
    3. Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility. Saberiyan M, et al. Reprod Sci, 2021 Jan. PMID 32749594
    4. Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. Neesen J, et al. Cytogenet Genome Res, 2002. PMID 12584439
    5. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. Rappold GA, et al. Genomics, 1992 Aug. PMID 1505969

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility.
      Title: Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility.
    2. TCTE3 is a useful marker of pancreatobiliary differentiation and may aid in the diagnosis of pancreatobiliary adenocarcinomas.
      Title: T-complex-associated-testis-expressed 3 (TCTE3) is a novel marker for pancreatobiliary carcinomas.
    3. Because TCTE3 encodes a putative light chain of the outer dynein arm of cilia and human diseases caused by ciliary dysfunction show various phenotypes including skeletal defect, TCTE3 may be a genetic candidate influencing CDH.
      Title: Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC142199

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein light chain Tctex-type protein 2
    Names
    T-complex testis-specific protein 3
    T-complex-associated testis-expressed protein 3
    Tctex1 domain containing 3
    t-complex-associated-testis-expressed 3
    tctex1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174910.3 → NP_777570.1  dynein light chain Tctex-type protein 2

      See identical proteins and their annotated locations for NP_777570.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AF519569, AL354892, BX089062
      Consensus CDS
      CCDS5310.1
      UniProtKB/Swiss-Prot
      Q8IZS6
      Related
      ENSP00000355736.3, ENST00000366774.4
      Conserved Domains (2) summary
      pfam03645
      Location:100 → 196
      Tctex-1; Tctex-1 family
      cl25363
      Location:11 → 72
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    RNA

    1. NR_138070.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is intronless and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC043594, BC063455
      Related
      ENST00000628156.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      169725091..169751572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715554.4 → XP_006715617.1  dynein light chain Tctex-type protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006715617.1

      Conserved Domains (1) summary
      pfam03645
      Location:43 → 136
      Tctex-1; Tctex-1 family

    2. XM_011536093.4 → XP_011534395.1  dynein light chain Tctex-type protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011534395.1

      UniProtKB/Swiss-Prot
      Q8IZS6
      Conserved Domains (2) summary
      pfam03645
      Location:100 → 196
      Tctex-1; Tctex-1 family
      cl25363
      Location:11 → 72
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187552.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      292..26774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328683.1 → XP_054184658.1  dynein light chain Tctex-type protein 2 isoform X2

    2. XM_054328682.1 → XP_054184657.1  dynein light chain Tctex-type protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8IZS6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      171079012..171105502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356278.1 → XP_054212253.1  dynein light chain Tctex-type protein 2 isoform X2

    2. XM_054356277.1 → XP_054212252.1  dynein light chain Tctex-type protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8IZS6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZS6.1 GenPept UniProtKB/Swiss-Prot:Q8IZS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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