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    GPR89B G protein-coupled receptor 89B [ Homo sapiens (human) ]

    Gene ID: 51463, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR89Bprovided by HGNC
    Official Full Name
    G protein-coupled receptor 89Bprovided by HGNC
    Primary source
    HGNC:HGNC:13840
    See related
    Ensembl:ENSG00000188092 MIM:612806; AllianceGenome:HGNC:13840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPHR; GPR89; SH120; GPR89C; UNQ192; LINC02804
    Summary
    Enables voltage-gated monoatomic anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: There are multiple copies of the sequence G protein-coupled receptor 89 in the human genome. After consultation with the HUGO Gene Nomenclature committee, the symbol GPR89B was assigned to the most telomeric locus. [06 Jun 2007]
    Expression
    Ubiquitous expression in kidney (RPKM 17.6), testis (RPKM 13.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GPR89B in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (147928420..148025934)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (146781476..146879130, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (147400533..147498175)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371229 Neighboring gene gap junction protein alpha 8 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:147420827-147421344 Neighboring gene PDZ domain containing 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145943675-145944386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145944387-145945098 Neighboring gene tRNA-Arg (anticodon CCT) 6-2 Neighboring gene RNA, U1 small nuclear 129, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145963909-145964683 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:147510508-147511043 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:147511044-147511580 Neighboring gene tRNA-Gln (anticodon CTG) 3-2 Neighboring gene RNA, variant U1 small nuclear 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Maeda Y, et al. Nat Cell Biol, 2008 Oct. PMID 18794847
    2. Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development. Van Alstyne M, et al. Biochem Biophys Res Commun, 2018 Nov 30. PMID 30352685, Free PMC Article
    3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
    4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    5. Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. Kattan RE, et al. Mol Cell Proteomics, 2022 Feb. PMID 35007762, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ55546, FLJ61382

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular pH reduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi pH regulator B
    Names
    G protein-coupled receptor 89C
    Golgi pH regulator A
    long intergenic non-protein coding RNA 2804
    protein GPR89
    putative Golgi pH regulator C
    putative MAPK-activating protein PM01
    putative NF-kappa-B-activating protein 90
    putative protein GPR89C

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001350180.2 → NP_001337109.1  Golgi pH regulator B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon structure in the 3' region compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AL133020, AW002571, AW137222, DB524598, U78723
      Consensus CDS
      CCDS930.1
      UniProtKB/Swiss-Prot
      A6NKF9, A6NN37, B2RUV3, B3KMN3, B4DLT3, B4DXE7, B7ZAQ6, P0CG08, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
      UniProtKB/TrEMBL
      X5D7G6, X5D920
      Conserved Domains (2) summary
      pfam12430
      Location:276 → 446
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:140 → 207
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    2. NM_001350181.2 → NP_001337110.1  Golgi pH regulator B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AL133020, AW002571, AW137222, DB459108, DC412954, U78723
      UniProtKB/TrEMBL
      X5D920
      Conserved Domains (2) summary
      pfam12430
      Location:251 → 419
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:115 → 182
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    3. NM_001350182.2 → NP_001337111.1  Golgi pH regulator B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AL133020, AW002571, AW137222, DC345007, DC412954, U78723
      UniProtKB/TrEMBL
      X5D920
      Conserved Domains (2) summary
      pfam12430
      Location:251 → 419
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:115 → 182
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    4. NM_001350183.2 → NP_001337112.1  Golgi pH regulator B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 3).
      Source sequence(s)
      AL133020, AW002571, AW137222, DA922006, DC412954, U78723
      UniProtKB/TrEMBL
      B4DY51
      Conserved Domains (2) summary
      pfam12430
      Location:156 → 324
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:20 → 87
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    5. NM_001350184.2 → NP_001337113.1  Golgi pH regulator B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate exon and uses an alternate splice site in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 3)
      Source sequence(s)
      AL133020, AW002571, AW137222, DA065783, DA922006, U78723
      UniProtKB/TrEMBL
      B4DY51
      Conserved Domains (2) summary
      pfam12430
      Location:156 → 324
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:20 → 87
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    6. NM_016334.5 → NP_057418.1  Golgi pH regulator B isoform 1

      See identical proteins and their annotated locations for NP_057418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AL133020, AW002571, AW137222, U78723
      Consensus CDS
      CCDS930.1
      UniProtKB/Swiss-Prot
      A6NKF9, A6NN37, B2RUV3, B3KMN3, B4DLT3, B4DXE7, B7ZAQ6, P0CG08, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
      UniProtKB/TrEMBL
      X5D7G6, X5D920
      Related
      ENSP00000358233.4, ENST00000314163.12
      Conserved Domains (2) summary
      pfam12430
      Location:276 → 446
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:140 → 207
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    RNA

    1. NR_183755.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC239801, AC239803

    2. NR_183756.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC239801, AC239803

    3. NR_183757.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC239801, AC239803

    4. NR_183758.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC239801, AC239803

    5. NR_183759.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC239801, AC239803

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      147928420..148025934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422467.1 → XP_047278423.1  Golgi pH regulator B isoform X2

    2. XM_017001449.2 → XP_016856938.1  Golgi pH regulator B isoform X3

      UniProtKB/TrEMBL
      X5D9J6
      Related
      ENSP00000475253.1, ENST00000468618.6

    3. XM_005277402.5 → XP_005277459.1  Golgi pH regulator B isoform X1

      See identical proteins and their annotated locations for XP_005277459.1

      UniProtKB/TrEMBL
      X5D920
      Conserved Domains (2) summary
      pfam12430
      Location:251 → 419
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:115 → 182
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    RNA

    1. XR_007060778.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      146781476..146879130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336966.1 → XP_054192941.1  Golgi pH regulator B isoform X1

    2. XM_054336968.1 → XP_054192943.1  Golgi pH regulator B isoform X3

    3. XM_054336967.1 → XP_054192942.1  Golgi pH regulator B isoform X2

    RNA

    1. XR_008486065.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001097616.1: Suppressed sequence

      Description
      NM_001097616.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CG08.1 GenPept UniProtKB/Swiss-Prot:P0CG08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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