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    SLC25A33 solute carrier family 25 member 33 [ Homo sapiens (human) ]

    Gene ID: 84275, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLC25A33provided by HGNC
    Official Full Name
    solute carrier family 25 member 33provided by HGNC
    Primary source
    HGNC:HGNC:29681
    See related
    Ensembl:ENSG00000171612 MIM:610816; AllianceGenome:HGNC:29681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PNC1; BMSC-MCP
    Summary
    SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 27.8), fat (RPKM 18.2) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC25A33 in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9539465..9585173)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9075801..9121512)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9599524..9645231)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9487788-9488422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 128 Neighboring gene long intergenic non-protein coding RNA 2606 Neighboring gene RNA, 5S ribosomal pseudogene 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9533371-9533922 Neighboring gene MPRA-validated peak54 silencer Neighboring gene Sharpr-MPRA regulatory region 9854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9601405-9601904 Neighboring gene MPRA-validated peak56 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 225 Neighboring gene hESC enhancers GRCh37_chr1:9653469-9654066 and GRCh37_chr1:9654067-9654663 Neighboring gene ribosomal protein L9 pseudogene 11 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:9657808-9659007 Neighboring gene transmembrane protein 201 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9671778-9672013 Neighboring gene uncharacterized LOC124903837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9675483-9676027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 226 Neighboring gene nonconserved acetylation island sequence 67 enhancer Neighboring gene uncharacterized LOC105376712 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables pyrimidine nucleotide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyrimidine nucleotide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to insulin-like growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondria-nucleus signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial genome maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyrimidine nucleotide import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyrimidine nucleotide import into mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyrimidine nucleotide import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pyrimidine nucleotide transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitochondrial membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    solute carrier family 25 member 33
    Names
    bone marrow stromal cell mitochondrial carrier protein
    huBMSC-MCP
    mitochondrial carrier protein
    novel mitochondrial carrier protein
    solute carrier family 25 (pyrimidine nucleotide carrier), member 33

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032315.3NP_115691.1  solute carrier family 25 member 33

      See identical proteins and their annotated locations for NP_115691.1

      Status: VALIDATED

      Source sequence(s)
      AL928921, AL954705, BC004991, BC073135
      Consensus CDS
      CCDS103.1
      UniProtKB/Swiss-Prot
      Q9BSK2
      Related
      ENSP00000306328.5, ENST00000302692.7
      Conserved Domains (1) summary
      pfam00153
      Location:7123
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      9539465..9585173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      9075801..9121512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)