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    CPNE2 copine 2 [ Homo sapiens (human) ]

    Gene ID: 221184, updated on 27-Nov-2024

    Summary

    Official Symbol
    CPNE2provided by HGNC
    Official Full Name
    copine 2provided by HGNC
    Primary source
    HGNC:HGNC:2315
    See related
    Ensembl:ENSG00000140848 MIM:604206; AllianceGenome:HGNC:2315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPN2; COPN2
    Summary
    Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 25.9), fat (RPKM 23.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CPNE2 in Genome Data Viewer
    Location:
    16q13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57092583..57148369)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62888853..62944643)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57126495..57182281)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57023277-57023776 Neighboring gene Sharpr-MPRA regulatory region 12884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57033747-57034248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10871 Neighboring gene NLR family CARD domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57060363-57060881 Neighboring gene CFAP69 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:57095254-57096453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57103335-57104060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57104061-57104785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57137039-57137994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57139274-57139873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7523 Neighboring gene Sharpr-MPRA regulatory region 3054 Neighboring gene Sharpr-MPRA regulatory region 6435 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57183845-57184634 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr16:57212532-57213113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7524 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:57220937-57221581 Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10885

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC16924, DKFZp686E06199

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152727.6NP_689940.3  copine-2

      See identical proteins and their annotated locations for NP_689940.3

      Status: REVIEWED

      Source sequence(s)
      AC009090, AF492484, BG830959, CB306539, CN283840, DB504175
      Consensus CDS
      CCDS10774.1
      UniProtKB/Swiss-Prot
      Q68D19, Q719H8, Q86XP9, Q96FN4
      UniProtKB/TrEMBL
      A8K8A4
      Related
      ENSP00000290776.8, ENST00000290776.13
      Conserved Domains (3) summary
      cd04047
      Location:155267
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:24141
      C2A_Copine; C2 domain first repeat in Copine
      pfam07002
      Location:326542
      Copine; Copine

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57092583..57148369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      62888853..62944643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)