ZCCHC3 zinc finger CCHC-type containing 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZCCHC3provided by HGNC
Official Full Name: zinc finger CCHC-type containing 3provided by HGNC
Primary source: HGNC:HGNC:16230
See related: Ensembl:ENSG00000247315 MIM:618326; AllianceGenome:HGNC:16230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C20orf99
Summary: Enables double-stranded DNA binding activity. Involved in cellular response to exogenous dsRNA; detection of virus; and positive regulation of innate immune response. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: mouse all
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Genomic context

Location:: 20p13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (297570..300321)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (340752..343503)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (278211..280965)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteomic analysis reveals zinc-finger CCHC-type containing protein 3 as a factor inhibiting virus infection by promoting innate signaling.
Title: Proteomic analysis reveals zinc-finger CCHC-type containing protein 3 as a factor inhibiting virus infection by promoting innate signaling.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Interaction of HIV-1 Gag with zinc finger, CCHC domain containing 3 (ZCCHC3) is identified in a series of six affinity purification/mass spectrometry screens	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC31957 (e-PCR)
- UniSTS:99846

SGC34218 (e-PCR)
- UniSTS:12152

WIAF-1720 (e-PCR)
- UniSTS:9851

WI-15102 (e-PCR)
- UniSTS:35257

HUMHM02E01 (e-PCR)
- UniSTS:1273

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of virus	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RIG-I signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RIG-I signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger CCHC domain-containing protein 3

Names: zinc finger, CCHC domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033089.7 → NP_149080.2 zinc finger CCHC domain-containing protein 3

See identical proteins and their annotated locations for NP_149080.2

Status: VALIDATED

Source sequence(s)

BC036469, BC069238

Consensus CDS

CCDS42844.1

UniProtKB/Swiss-Prot

Q3B7J3, Q6NT79, Q9NUD5

Related

ENSP00000484056.1, ENST00000500893.4

Conserved Domains (1) summary

cl26705
Location:333 → 386

AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]