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    SLC27A1 solute carrier family 27 member 1 [ Homo sapiens (human) ]

    Gene ID: 376497, updated on 3-Dec-2024

    Summary

    Official Symbol
    SLC27A1provided by HGNC
    Official Full Name
    solute carrier family 27 member 1provided by HGNC
    Primary source
    HGNC:HGNC:10995
    See related
    Ensembl:ENSG00000130304 MIM:600691; AllianceGenome:HGNC:10995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FATP; FATP1; ACSVL5; FATP-1
    Summary
    Enables biotin transmembrane transporter activity; efflux transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including glycerophospholipid biosynthetic process; lipid transport across blood-brain barrier; and monocarboxylic acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 10.2), fat (RPKM 9.1) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC27A1 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17468767..17506168)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17602871..17640805)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17581333..17616977)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10345 Neighboring gene transmembrane protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17571641-17572141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14273 Neighboring gene nucleoredoxin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17581949-17582450 Neighboring gene Sharpr-MPRA regulatory region 2801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17593839-17594340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14275 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17599959-17600122 Neighboring gene PGLS divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17609403-17609947 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17610300-17611168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17611169-17612037 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:17618299-17619498 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17621304-17621961 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17621962-17622618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10350 Neighboring gene Sharpr-MPRA regulatory region 7913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17623276-17623931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14278 Neighboring gene 6-phosphogluconolactonase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17641583-17642201 Neighboring gene niban apoptosis regulator 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10354

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Messenger RNAs for three proteins AATK, SLC27A1, and CDKAL1 are preferentially secreted out in exosomes from HIV-1 Nef-expressing cells, and their targeting miRNAs (miR-32 and miR-93*) are retained in these cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ00336, MGC71751

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arachidonate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables biotin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables fatty acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleoyl-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oleoyl-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables very long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biotin import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in biotin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cardiolipin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose import in response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid transport across blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid import into cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid transport TAS
    Traceable Author Statement
    more info
     
    involved_in medium-chain fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylethanolamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylglycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylserine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of heat generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to cold IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    long-chain fatty acid transport protein 1
    Names
    arachidonate--CoA ligase
    fatty acid transport protein 1
    long-chain-fatty-acid--CoA ligase
    solute carrier family 27 (fatty acid transporter), member 1
    very long-chain acyl-CoA synthetase
    NP_940982.1
    XP_011526302.1
    XP_011526304.1
    XP_011526305.1
    XP_047294745.1
    XP_047294746.1
    XP_047294747.1
    XP_047294748.1
    XP_054176910.1
    XP_054176911.1
    XP_054176912.1
    XP_054176913.1
    XP_054176914.1
    XP_054176915.1
    XP_054176916.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198580.3NP_940982.1  long-chain fatty acid transport protein 1

      See identical proteins and their annotated locations for NP_940982.1

      Status: VALIDATED

      Source sequence(s)
      AC010618, BC059399
      Consensus CDS
      CCDS32953.1
      UniProtKB/Swiss-Prot
      A6NIH2, B7Z662, Q6PCB7
      UniProtKB/TrEMBL
      B7Z3U1
      Related
      ENSP00000252595.6, ENST00000252595.12
      Conserved Domains (3) summary
      PRK08279
      Location:42644
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:101611
      AFD_class_I; Adenylate forming domain, Class I superfamily
      cl23716
      Location:64135
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      17468767..17506168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528000.2XP_011526302.1  long-chain fatty acid transport protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011526302.1

      UniProtKB/TrEMBL
      B7Z3U1
      Conserved Domains (3) summary
      PRK08279
      Location:42656
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:101623
      AFD_class_I; Adenylate forming domain, Class I superfamily
      cl23716
      Location:64135
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    2. XM_011528003.3XP_011526305.1  long-chain fatty acid transport protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011526305.1

      UniProtKB/Swiss-Prot
      A6NIH2, B7Z662, Q6PCB7
      UniProtKB/TrEMBL
      B7Z3U1
      Conserved Domains (3) summary
      PRK08279
      Location:42644
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:101611
      AFD_class_I; Adenylate forming domain, Class I superfamily
      cl23716
      Location:64135
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    3. XM_011528002.3XP_011526304.1  long-chain fatty acid transport protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011526304.1

      UniProtKB/TrEMBL
      B7Z3U1
      Conserved Domains (3) summary
      PRK08279
      Location:42656
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:101623
      AFD_class_I; Adenylate forming domain, Class I superfamily
      cl23716
      Location:64135
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    4. XM_047438789.1XP_047294745.1  long-chain fatty acid transport protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A6NIH2, B7Z662, Q6PCB7
      UniProtKB/TrEMBL
      B7Z3U1
    5. XM_047438790.1XP_047294746.1  long-chain fatty acid transport protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A6NIH2, B7Z662, Q6PCB7
      UniProtKB/TrEMBL
      B7Z3U1
    6. XM_047438791.1XP_047294747.1  long-chain fatty acid transport protein 1 isoform X3

    7. XM_047438792.1XP_047294748.1  long-chain fatty acid transport protein 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      17602871..17640805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320939.1XP_054176914.1  long-chain fatty acid transport protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A6NIH2, B7Z662, Q6PCB7
      UniProtKB/TrEMBL
      B7Z3U1
    2. XM_054320935.1XP_054176910.1  long-chain fatty acid transport protein 1 isoform X1

      UniProtKB/TrEMBL
      B7Z3U1
    3. XM_054320937.1XP_054176912.1  long-chain fatty acid transport protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A6NIH2, B7Z662, Q6PCB7
      UniProtKB/TrEMBL
      B7Z3U1
    4. XM_054320936.1XP_054176911.1  long-chain fatty acid transport protein 1 isoform X1

      UniProtKB/TrEMBL
      B7Z3U1
    5. XM_054320938.1XP_054176913.1  long-chain fatty acid transport protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A6NIH2, B7Z662, Q6PCB7
      UniProtKB/TrEMBL
      B7Z3U1
    6. XM_054320940.1XP_054176915.1  long-chain fatty acid transport protein 1 isoform X3

    7. XM_054320941.1XP_054176916.1  long-chain fatty acid transport protein 1 isoform X4