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    PLAC9 placenta associated 9 [ Homo sapiens (human) ]

    Gene ID: 219348, updated on 27-Nov-2024

    Summary

    Official Symbol
    PLAC9provided by HGNC
    Official Full Name
    placenta associated 9provided by HGNC
    Primary source
    HGNC:HGNC:19255
    See related
    Ensembl:ENSG00000189129 MIM:612857; AllianceGenome:HGNC:19255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in fat (RPKM 55.2), prostate (RPKM 10.1) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PLAC9 in Genome Data Viewer
    Location:
    10q22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (80131661..80145359)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (81000769..81014482)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81891417..81905115)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene TMEM254 antisense RNA 1 Neighboring gene transmembrane protein 254 Neighboring gene ribosomal protein L22 pseudogene 18 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:81917938-81919137 Neighboring gene annexin A11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81928334-81928862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81931132-81932057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81936179-81936680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81936681-81937180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81937700-81938200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81945900-81946400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81954116-81954792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81954793-81955468 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:81955517-81956716 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2544 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:81966703-81967902 Neighboring gene long intergenic non-protein coding RNA 857 Neighboring gene ribosomal protein S12 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    placenta-specific protein 9
    Names
    placenta specific 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012973.3NP_001012991.1  placenta-specific protein 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001012991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL356095
      Consensus CDS
      CCDS31232.1
      UniProtKB/Swiss-Prot
      Q5JTB6
      Related
      ENSP00000361337.3, ENST00000372263.4
      Conserved Domains (1) summary
      pfam15205
      Location:2396
      PLAC9; Placenta-specific protein 9
    2. NM_001331125.2NP_001318054.1  placenta-specific protein 9 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA460691, AL356095, BC066348, BU731023
      Consensus CDS
      CCDS86126.1
      UniProtKB/TrEMBL
      Q5JTB5
      Related
      ENSP00000361341.2, ENST00000372267.6

    RNA

    1. NR_138551.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL356095, BU731023, EL950785

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      80131661..80145359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      81000769..81014482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364994.1XP_054220969.1  placenta-specific protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q5JTB6