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    CIAPIN1 cytokine induced apoptosis inhibitor 1 [ Homo sapiens (human) ]

    Gene ID: 57019, updated on 27-Nov-2024

    Summary

    Official Symbol
    CIAPIN1provided by HGNC
    Official Full Name
    cytokine induced apoptosis inhibitor 1provided by HGNC
    Primary source
    HGNC:HGNC:28050
    See related
    Ensembl:ENSG00000005194 MIM:608943; AllianceGenome:HGNC:28050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRE2; CIAE2; PRO0915; Anamorsin
    Summary
    CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 38.4), placenta (RPKM 14.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CIAPIN1 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57428187..57447385, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63223362..63242561, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57462099..57481297, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57412503-57413083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10892 Neighboring gene C-X3-C motif chemokine ligand 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57417624-57418314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57418315-57419004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10894 Neighboring gene C-C motif chemokine ligand 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57450029-57450544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57450545-57451060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57451577-57452091 Neighboring gene Sharpr-MPRA regulatory region 5957 Neighboring gene coenzyme Q9 Neighboring gene Sharpr-MPRA regulatory region 83 Neighboring gene RNA polymerase II subunit C Neighboring gene docking protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    anamorsin
    Names
    fe-S cluster assembly protein DRE2 homolog
    predicted protein of HQ0915

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308347.2NP_001295276.1  anamorsin isoform 2

      See identical proteins and their annotated locations for NP_001295276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 2.
      Source sequence(s)
      AC009052, AL136613
      Consensus CDS
      CCDS76876.1
      UniProtKB/Swiss-Prot
      Q6FI81
      Related
      ENSP00000456114.1, ENST00000567518.5
      Conserved Domains (1) summary
      pfam05093
      Location:227291
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
    2. NM_001308358.2NP_001295287.1  anamorsin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1. The encoded isoform (3)
      Source sequence(s)
      AF248964, BC067303, BG746807, BJ991015
      Consensus CDS
      CCDS76877.1
      UniProtKB/TrEMBL
      H3BPG7, H3BT65
      Related
      ENSP00000457042.1, ENST00000569370.5
      Conserved Domains (1) summary
      cl17173
      Location:395
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_020313.4NP_064709.2  anamorsin isoform 1

      See identical proteins and their annotated locations for NP_064709.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF248964, BC024196, BC067303
      Consensus CDS
      CCDS10781.2
      UniProtKB/Swiss-Prot
      A8K8B6, O75206, O75207, Q6FI81, Q9H0W1, Q9P1L7
      Related
      ENSP00000377914.4, ENST00000394391.9
      Conserved Domains (2) summary
      pfam05093
      Location:240304
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
      cl17173
      Location:395
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57428187..57447385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63223362..63242561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)