U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DDX19B DEAD-box helicase 19B [ Homo sapiens (human) ]

    Gene ID: 11269, updated on 27-Nov-2024

    Summary

    Official Symbol
    DDX19Bprovided by HGNC
    Official Full Name
    DEAD-box helicase 19Bprovided by HGNC
    Primary source
    HGNC:HGNC:2742
    See related
    Ensembl:ENSG00000157349 MIM:605812; AllianceGenome:HGNC:2742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBP5; RNAh; DDX19
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 16.5), thyroid (RPKM 10.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DDX19B in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70289767..70335305)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (76100775..76146326)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70323670..70369208)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:70286884-70287384 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70294233-70294475 Neighboring gene exosome component 6 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70317824-70318022 Neighboring gene RNA, 7SL, cytoplasmic 279, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7671 Neighboring gene Sharpr-MPRA regulatory region 7868 Neighboring gene DDX19A divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:70366483-70367682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70379806-70380424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70380425-70381042 Neighboring gene DEAD-box helicase 19A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11055 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70421141-70421825 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11057 Neighboring gene uncharacterized LOC124903707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70458653-70459478

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA export from nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
     
    part_of nuclear pore TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX19B
    Names
    ATP-dependent RNA helicase DDX19
    DEAD (Asp-Glu-Ala-As) box polypeptide 19B
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
    DEAD box protein 19B
    DEAD-box RNA helicase DEAD5
    DEAD-box protein 5
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5, yeast, homolog)
    dead box protein 5 homolog
    yeast Dbp5 homolog
    NP_001014449.1
    NP_001014451.1
    NP_001244101.1
    NP_001244102.1
    NP_001244103.1
    NP_001244104.1
    NP_001350867.1
    NP_009173.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014449.3NP_001014449.1  ATP-dependent RNA helicase DDX19B isoform 3

      See identical proteins and their annotated locations for NP_001014449.1

      Status: REVIEWED

      Source sequence(s)
      AC012184, BC003626, BC010008, BI756088, DC385044
      Consensus CDS
      CCDS42187.1
      UniProtKB/TrEMBL
      Q69YM2
      Related
      ENSP00000377267.2, ENST00000393657.6
      Conserved Domains (1) summary
      COG0513
      Location:1369
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    2. NM_001014451.3NP_001014451.1  ATP-dependent RNA helicase DDX19B isoform 2

      See identical proteins and their annotated locations for NP_001014451.1

      Status: REVIEWED

      Source sequence(s)
      AC012184, AL136639, BC003626, BI756088, DC385044
      Consensus CDS
      CCDS32475.1
      UniProtKB/TrEMBL
      B4DS24
      Related
      ENSP00000348271.3, ENST00000355992.7
      Conserved Domains (1) summary
      COG0513
      Location:101447
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    3. NM_001257172.2NP_001244101.1  ATP-dependent RNA helicase DDX19B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC012184, AK302107
      Consensus CDS
      CCDS58478.1
      UniProtKB/TrEMBL
      B4DS24
      Related
      ENSP00000392639.3, ENST00000451014.7
      Conserved Domains (3) summary
      COG0513
      Location:106452
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:281416
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:105270
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. NM_001257173.2NP_001244102.1  ATP-dependent RNA helicase DDX19B isoform 3

      See identical proteins and their annotated locations for NP_001244102.1

      Status: REVIEWED

      Source sequence(s)
      AC012184, AK301938
      Consensus CDS
      CCDS42187.1
      UniProtKB/TrEMBL
      Q69YM2
      Related
      ENSP00000456757.1, ENST00000568625.5
      Conserved Domains (1) summary
      COG0513
      Location:1369
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    5. NM_001257174.2NP_001244103.1  ATP-dependent RNA helicase DDX19B isoform 3

      See identical proteins and their annotated locations for NP_001244103.1

      Status: REVIEWED

      Source sequence(s)
      AC012184, AF353720
      Consensus CDS
      CCDS42187.1
      UniProtKB/TrEMBL
      Q69YM2
      Related
      ENSP00000456574.1, ENST00000563392.5
      Conserved Domains (1) summary
      COG0513
      Location:1369
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    6. NM_001257175.2NP_001244104.1  ATP-dependent RNA helicase DDX19B isoform 5

      See identical proteins and their annotated locations for NP_001244104.1

      Status: REVIEWED

      Source sequence(s)
      AC012184, AK296868, DC385044
      UniProtKB/TrEMBL
      B4DL69, Q69YM2
      Conserved Domains (2) summary
      COG0513
      Location:9327
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cl28899
      Location:1145
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    7. NM_001363938.1NP_001350867.1  ATP-dependent RNA helicase DDX19B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC012184
      Consensus CDS
      CCDS86540.1
      UniProtKB/TrEMBL
      H3BQK0, Q2NL95
      Related
      ENSP00000455813.1, ENST00000563206.5
      Conserved Domains (1) summary
      COG0513
      Location:95483
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    8. NM_007242.7NP_009173.1  ATP-dependent RNA helicase DDX19B isoform 1

      See identical proteins and their annotated locations for NP_009173.1

      Status: REVIEWED

      Source sequence(s)
      AC012184
      Consensus CDS
      CCDS10888.1
      UniProtKB/Swiss-Prot
      B3KNE9, B4DXS6, E7EMK4, Q6FIB7, Q6IAE0, Q96KE7, Q9H0U0, Q9UMR2
      UniProtKB/TrEMBL
      A0A0U4B4U6, Q53G16
      Related
      ENSP00000288071.7, ENST00000288071.11
      Conserved Domains (2) summary
      cd18787
      Location:307443
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cl28899
      Location:75303
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      70289767..70335305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      76100775..76146326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)