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    FGF10 fibroblast growth factor 10 [ Homo sapiens (human) ]

    Gene ID: 2255, updated on 9-Dec-2024

    Summary

    Official Symbol
    FGF10provided by HGNC
    Official Full Name
    fibroblast growth factor 10provided by HGNC
    Primary source
    HGNC:HGNC:3666
    See related
    Ensembl:ENSG00000070193 MIM:602115; AllianceGenome:HGNC:3666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LADD3
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in ovary (RPKM 9.2), fat (RPKM 4.7) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FGF10 in Genome Data Viewer
    Location:
    5p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (44300247..44389420, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (44553832..44642982, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (44300349..44389522, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85370 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85375 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43708151-43708652 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43717701-43718325 Neighboring gene ribosomal protein L29 pseudogene 12 Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43745853-43746524 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85421 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85427 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85485 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85525 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85570 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85621 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85633 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85647 Neighboring gene RNA, U6 small nuclear 381, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85852 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85853 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85873 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:44236336-44236856 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:44262669-44262835 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:44328940-44329154 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85945 Neighboring gene VISTA enhancer hs516 Neighboring gene FGF10 intronic enhancer Neighboring gene FGF10 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 2224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:44641710-44642210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:44664054-44664554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:44664555-44665055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:44669147-44669815 Neighboring gene RNA, 7SL, cytoplasmic 383, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Congenital absence of salivary gland
    MedGen: C0158667 OMIM: 180920 GeneReviews: Not available
    Compare labs
    Lacrimoauriculodentodigital syndrome 3
    MedGen: C5774287 OMIM: 620193 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2022-02-23)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2022-02-23)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of fibroblast growth factor 10 (FGF10) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemoattractant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibroblast growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type 2 fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 2 fibroblast growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Harderian gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branch elongation involved in salivary gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching morphogenesis of an epithelial tube IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in bronchiole morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bud elongation involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bud outgrowth involved in lung branching IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic genitalia morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial cell proliferation involved in salivary gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female genitalia morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway involved in mammary gland specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in induction of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lacrimal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb bud formation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lung epithelium development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lung proximal/distal axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung saccule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male genitalia morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland bud formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal cell differentiation involved in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal-epithelial cell signaling involved in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesonephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in metanephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in metanephros morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organ induction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in otic vesicle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pituitary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation involved in wound healing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hair follicle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of keratinocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of keratinocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lymphocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of urothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of urothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of white fat cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostatic bud formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in radial glial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of activin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of saliva secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in secretion by lung epithelial cell involved in lung growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in semicircular canal fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in submandibular salivary gland formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tear secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in thymus development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type II pneumocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in white fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in white fat cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface NAS
    Non-traceable Author Statement
    more info
    PubMed 
    colocalizes_with collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fibroblast growth factor 10
    Names
    FGF-10
    keratinocyte growth factor 2
    produced by fibroblasts of urinary bladder lamina propria

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011446.1 RefSeqGene

      Range
      5001..88688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004465.2NP_004456.1  fibroblast growth factor 10 precursor

      See identical proteins and their annotated locations for NP_004456.1

      Status: REVIEWED

      Source sequence(s)
      AB002097, AC093537, BX955123, DA795795, DR003252
      Consensus CDS
      CCDS3950.1
      UniProtKB/Swiss-Prot
      C7FDY0, O15520, Q6FHR3, Q6FHT6, Q96P59
      UniProtKB/TrEMBL
      A0A7U3JW18, Q8NFI9
      Related
      ENSP00000264664.4, ENST00000264664.5
      Conserved Domains (1) summary
      pfam00167
      Location:78202
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      44300247..44389420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005248264.5XP_005248321.1  fibroblast growth factor 10 isoform X1

      See identical proteins and their annotated locations for XP_005248321.1

      UniProtKB/Swiss-Prot
      C7FDY0, O15520, Q6FHR3, Q6FHT6, Q96P59
      UniProtKB/TrEMBL
      A0A7U3JW18, Q8NFI9
      Conserved Domains (1) summary
      pfam00167
      Location:78202
      FGF; Fibroblast growth factor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      44553832..44642982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)