DUSP8 dual specificity phosphatase 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DUSP8provided by HGNC
Official Full Name: dual specificity phosphatase 8provided by HGNC
Primary source: HGNC:HGNC:3074
See related: Ensembl:ENSG00000184545 MIM:602038; AllianceGenome:HGNC:3074
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HB5; HVH8; HVH-5; C11orf81
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]
Expression: Broad expression in brain (RPKM 9.1), colon (RPKM 3.4) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (1554051..1572848, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (1635383..1654159, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (1575281..1593501, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-147b mediated suppression of DUSP8 promotes lung cancer progression.
Title: miR-147b mediated suppression of DUSP8 promotes lung cancer progression.
DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha.
Title: DUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α.
Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways.
Title: Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways.
Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
Title: Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
The phosphorylation of the M3/6 phosphatase by JNK in response to stress stimuli results in attenuation of phosphatase activity and acceleration of JNK activation.
Title: Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite.
Because this variant of hVH-5 lacked intronic sequences in its genomic structure, we suggest it might be a processed pseudogene of hVH-5.
Title: Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2.
DUSP8 is genetically linked to alcohol dependence and was found on chromosome 11p15.5
Title: Investigation of DUSP8 and CALCA in alcohol dependence.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103770 (e-PCR)
- UniSTS:98095

RH70588 (e-PCR)
- UniSTS:86880

Dusp8 (e-PCR), detects polymorphism
- UniSTS:266977

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dual specificity protein phosphatase 8

Names: H1 phosphatase, vaccinia virus homolog; dual specificity protein phosphatase hVH-5; serine/threonine specific protein phosphatase

NP_004411.2

EC 3.1.3.16

EC 3.1.3.48

XP_011518234.1

EC 3.1.3.16

EC 3.1.3.48

XP_011518235.1

EC 3.1.3.16

EC 3.1.3.48

XP_047282469.1

EC 3.1.3.16

EC 3.1.3.48

XP_054184836.1

EC 3.1.3.16

EC 3.1.3.48

XP_054184837.1

EC 3.1.3.16

EC 3.1.3.48

XP_054184838.1

EC 3.1.3.16

EC 3.1.3.48

XP_054185959.1

EC 3.1.3.16

EC 3.1.3.48

XP_054185960.1

EC 3.1.3.16

EC 3.1.3.48

XP_054185961.1

EC 3.1.3.16

EC 3.1.3.48

XP_054189085.1

EC 3.1.3.16

EC 3.1.3.48

XP_054189086.1

EC 3.1.3.16

EC 3.1.3.48

XP_054189087.1

EC 3.1.3.16

EC 3.1.3.48

XP_054223912.1

EC 3.1.3.16

EC 3.1.3.48

XP_054223913.1

EC 3.1.3.16

EC 3.1.3.48

XP_054223914.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004420.3 → NP_004411.2 dual specificity protein phosphatase 8

See identical proteins and their annotated locations for NP_004411.2

Status: REVIEWED

Source sequence(s)

AK124467, AP006285, BC045110, BU740880, U27193

Consensus CDS

CCDS7724.1

UniProtKB/Swiss-Prot

Q13202, Q86SS8

Related

ENSP00000380530.3, ENST00000397374.8

Conserved Domains (2) summary

cd00127
Location:160 → 297

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:10 → 137

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

1554051..1572848 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011519933.3 → XP_011518235.1 dual specificity protein phosphatase 8 isoform X1

See identical proteins and their annotated locations for XP_011518235.1

UniProtKB/Swiss-Prot

Q13202, Q86SS8

Related

ENSP00000329539.4, ENST00000331588.4

Conserved Domains (2) summary

cd00127
Location:160 → 297

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:10 → 137

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
XM_047426513.1 → XP_047282469.1 dual specificity protein phosphatase 8 isoform X2
XM_011519932.3 → XP_011518234.1 dual specificity protein phosphatase 8 isoform X1

See identical proteins and their annotated locations for XP_011518234.1

UniProtKB/Swiss-Prot

Q13202, Q86SS8

Conserved Domains (2) summary

cd00127
Location:160 → 297

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:10 → 137

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

Reference GRCh38.p14 PATCHES

Genomic

NW_025791792.1 Reference GRCh38.p14 PATCHES

Range

294027..312824 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333111.1 → XP_054189086.1 dual specificity protein phosphatase 8 isoform X1

UniProtKB/Swiss-Prot

Q13202, Q86SS8
XM_054333112.1 → XP_054189087.1 dual specificity protein phosphatase 8 isoform X2
XM_054333110.1 → XP_054189085.1 dual specificity protein phosphatase 8 isoform X1

UniProtKB/Swiss-Prot

Q13202, Q86SS8

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187584.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

36288..55085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328862.1 → XP_054184837.1 dual specificity protein phosphatase 8 isoform X1

UniProtKB/Swiss-Prot

Q13202, Q86SS8
XM_054328863.1 → XP_054184838.1 dual specificity protein phosphatase 8 isoform X2
XM_054328861.1 → XP_054184836.1 dual specificity protein phosphatase 8 isoform X1

UniProtKB/Swiss-Prot

Q13202, Q86SS8

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_187657.1 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

30578..49375 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329985.1 → XP_054185960.1 dual specificity protein phosphatase 8 isoform X1

UniProtKB/Swiss-Prot

Q13202, Q86SS8
XM_054329986.1 → XP_054185961.1 dual specificity protein phosphatase 8 isoform X2
XM_054329984.1 → XP_054185959.1 dual specificity protein phosphatase 8 isoform X1

UniProtKB/Swiss-Prot

Q13202, Q86SS8

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

1635383..1654159 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367938.1 → XP_054223913.1 dual specificity protein phosphatase 8 isoform X1

UniProtKB/Swiss-Prot

Q13202, Q86SS8
XM_054367939.1 → XP_054223914.1 dual specificity protein phosphatase 8 isoform X2
XM_054367937.1 → XP_054223912.1 dual specificity protein phosphatase 8 isoform X1

UniProtKB/Swiss-Prot

Q13202, Q86SS8