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    EMB embigin [ Homo sapiens (human) ]

    Gene ID: 133418, updated on 27-Nov-2024

    Summary

    Official Symbol
    EMBprovided by HGNC
    Official Full Name
    embiginprovided by HGNC
    Primary source
    HGNC:HGNC:30465
    See related
    Ensembl:ENSG00000170571 MIM:615669; AllianceGenome:HGNC:30465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP70
    Summary
    This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in bone marrow (RPKM 76.3), duodenum (RPKM 39.2) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EMB in Genome Data Viewer
    Location:
    5q11.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (50396192..50443345, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (51215328..51262447, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (49692026..49737122, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901180 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:45288792-45289361 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:45385335-45386534 Neighboring gene NANOG hESC enhancer GRCh37_chr5:45398997-45399517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45694855-45695356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45695357-45695856 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:45722136-45723335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:45847424-45848170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:45848171-45848917 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46322424-46322954 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46324015-46324544 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46323485-46324014 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46339317-46339850 Neighboring gene NANOG hESC enhancer GRCh37_chr5:46362710-46363410 Neighboring gene NANOG hESC enhancer GRCh37_chr5:46382059-46382560 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49410739-49411304 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49411305-49411870 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:49429185-49430023 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49422693-49423236 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49428344-49429184 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:49418829-49419370 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49423237-49423778 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49431703-49432542 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49432543-49433382 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49433383-49434222 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:49436741-49437580 Neighboring gene NANOG hESC enhancer GRCh37_chr5:49539003-49539504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16001 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:49963094-49964293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22543 Neighboring gene peptidylprolyl isomerase A like 4G pseudogene Neighboring gene poly(ADP-ribose) polymerase family member 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC71745

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane lactate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    embigin
    Names
    embigin homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198449.3NP_940851.1  embigin precursor

      See identical proteins and their annotated locations for NP_940851.1

      Status: REVIEWED

      Source sequence(s)
      AC091833, BC059398
      Consensus CDS
      CCDS3953.1
      UniProtKB/Swiss-Prot
      B7Z6S3, B7Z902, Q6PCB8
      UniProtKB/TrEMBL
      D6RDX7
      Related
      ENSP00000302289.5, ENST00000303221.10
      Conserved Domains (2) summary
      smart00410
      Location:172254
      IG_like; Immunoglobulin like
      cl11960
      Location:82143
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      50396192..50443345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543146.3XP_011541448.1  embigin isoform X1

      See identical proteins and their annotated locations for XP_011541448.1

      UniProtKB/Swiss-Prot
      Q6PCB8
      Conserved Domains (3) summary
      cd00096
      Location:127201
      Ig; Immunoglobulin domain
      smart00410
      Location:122204
      IG_like; Immunoglobulin like
      cl11960
      Location:3293
      Ig; Immunoglobulin domain
    2. XM_047416702.1XP_047272658.1  embigin isoform X1

      Related
      ENSP00000426404.1, ENST00000514111.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      51215328..51262447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351576.1XP_054207551.1  embigin isoform X1