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    Hdac10 histone deacetylase 10 [ Mus musculus (house mouse) ]

    Gene ID: 170787, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Hdac10provided by MGI
    Official Full Name
    histone deacetylase 10provided by MGI
    Primary source
    MGI:MGI:2158340
    See related
    Ensembl:ENSMUSG00000062906 AllianceGenome:MGI:2158340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hd10
    Summary
    Predicted to enable histone deacetylase activity; histone deacetylase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of mismatch repair; regulation of gene expression; and spermidine deacetylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 30.7), thymus adult (RPKM 25.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hdac10 in Genome Data Viewer
    Location:
    15 E3; 15 44.64 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89007506..89012903, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89123303..89128700, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene TraB domain containing Neighboring gene selenoprotein O Neighboring gene tubulin, gamma complex component 6 Neighboring gene STARR-positive B cell enhancer ABC_E5508 Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene mitogen-activated protein kinase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165. Xiang Y, et al. Respir Res, 2024 Jul 2. PMID 38956592, Free PMC Article
    2. Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses. Zhou W, et al. Sci Signal, 2022 Dec 20. PMID 36538592
    3. HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma. Li Y, et al. Cancer Res, 2020 Aug 15. PMID 32540961, Free PMC Article
    4. Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. Liu F, et al. J Mol Cell Cardiol, 2008 Dec. PMID 18926829, Free PMC Article
    5. HDAC10 deletion promotes Foxp3(+) T-regulatory cell function. Dahiya S, et al. Sci Rep, 2020 Jan 16. PMID 31949209, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165.
      Title: Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165.
    2. Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses.
      Title: Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses.
    3. HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma.
      Title: HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma.
    4. HDAC10 deletion promotes Foxp3(+) T-regulatory cell function.
      Title: HDAC10 deletion promotes Foxp3(+) T-regulatory cell function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylputrescine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylspermidine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein lysine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables protein lysine deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macroautophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyamine deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyamine deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermidine deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermidine deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyamine deacetylase HDAC10
    NP_001403078.1
    NP_001403079.1
    NP_001403080.1
    NP_001403081.1
    NP_001403082.1
    NP_001403083.1
    NP_001403084.1
    NP_001403085.1
    NP_001403086.1
    NP_001403087.1
    NP_001403088.1
    NP_001403089.1
    NP_001403090.1
    NP_001403091.1
    NP_954668.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416149.1 → NP_001403078.1  polyamine deacetylase HDAC10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113069

    2. NM_001416150.1 → NP_001403079.1  polyamine deacetylase HDAC10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113069

    3. NM_001416151.1 → NP_001403080.1  polyamine deacetylase HDAC10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113069

    4. NM_001416152.1 → NP_001403081.1  polyamine deacetylase HDAC10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113069

    5. NM_001416153.1 → NP_001403082.1  polyamine deacetylase HDAC10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC113069

    6. NM_001416154.1 → NP_001403083.1  polyamine deacetylase HDAC10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC113069

    7. NM_001416155.1 → NP_001403084.1  polyamine deacetylase HDAC10 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC113069

    8. NM_001416156.1 → NP_001403085.1  polyamine deacetylase HDAC10 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC113069

    9. NM_001416157.1 → NP_001403086.1  polyamine deacetylase HDAC10 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC113069

    10. NM_001416158.1 → NP_001403087.1  polyamine deacetylase HDAC10 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC113069

    11. NM_001416159.1 → NP_001403088.1  polyamine deacetylase HDAC10 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC113069

    12. NM_001416160.1 → NP_001403089.1  polyamine deacetylase HDAC10 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC113069

    13. NM_001416161.1 → NP_001403090.1  polyamine deacetylase HDAC10 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC113069

    14. NM_001416162.1 → NP_001403091.1  polyamine deacetylase HDAC10 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC113069

    15. NM_199198.3 → NP_954668.2  polyamine deacetylase HDAC10 isoform 1

      See identical proteins and their annotated locations for NP_954668.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      AC113069
      Consensus CDS
      CCDS27739.1
      UniProtKB/Swiss-Prot
      G3X9I8, Q6P3E7
      Related
      ENSMUSP00000080832.6, ENSMUST00000082197.12
      Conserved Domains (1) summary
      cl17011
      Location:18 → 354
      Arginase_HDAC; Arginase-like and histone-like hydrolases

    RNA

    1. NR_028447.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC113069, AI448228, AK040235, BU706947
      Related
      ENSMUST00000129398.8

    2. NR_028448.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC113069, AI448228, AK040235
      Related
      ENSMUST00000128908.8

    3. NR_028449.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC113069, AI448228, AK040235, BU706947
      Related
      ENSMUST00000143465.8

    4. NR_183467.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113069

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89007506..89012903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3E7.2 GenPept UniProtKB/Swiss-Prot:Q6P3E7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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