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    Asb1 ankyrin repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 65247, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Asb1provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 1provided by MGI
    Primary source
    MGI:MGI:1929735
    See related
    Ensembl:ENSMUSG00000026311 AllianceGenome:MGI:1929735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1146; 1700029O08Rik; 1700054C17Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within male genitalia development. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB1 (ankyrin repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 17.6), liver E14 (RPKM 5.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asb1 in Genome Data Viewer
    Location:
    1 D; 1 46.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91467725..91487312)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91540001..91559590)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nucleolar complex associated 3 homolog pseudogene Neighboring gene TRAF3 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_01698 Neighboring gene STARR-positive B cell enhancer ABC_E1555 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93497438-93497621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93498155-93498356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93527619-93527999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93529086-93529287 Neighboring gene predicted gene 28380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93547237-93547420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93555659-93555944 Neighboring gene STARR-seq mESC enhancer starr_01699 Neighboring gene STARR-seq mESC enhancer starr_01700 Neighboring gene twist basic helix-loop-helix transcription factor 2 Neighboring gene predicted gene, 46117

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis. Hou P, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33431678, Free PMC Article
    2. Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model. Emeny RT, et al. Neuropsychopharmacology, 2018 Jan. PMID 28540928, Free PMC Article
    3. Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. de Ledesma AM, et al. Mamm Genome, 2006 Feb. PMID 16465591
    4. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Kile BT, et al. Gene, 2000 Nov 27. PMID 11111040
    5. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An unconventional role of an ASB family protein in NF-kappaB activation and inflammatory response during microbial infection and colitis.
      Title: An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis.
    2. In murine acute social defeat stress, Asb1 gene expression is significantly upregulated in a tissue-specific manner (p=0.006), which correlates with upregulation of the neuroimmunomodulating cytokine interleukin 1 beta.
      Title: Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 1
    Names
    ASB-1
    ankyrin repeat and SOCS box-containing protein 1
    ankyrin repeat-containing SOCS box protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039126.2 → NP_001034215.1  ankyrin repeat and SOCS box protein 1 isoform a

      See identical proteins and their annotated locations for NP_001034215.1

      Status: VALIDATED

      Source sequence(s)
      AC109199, AK153774, BY231875
      Consensus CDS
      CCDS35665.1
      UniProtKB/Swiss-Prot
      Q9WV74
      UniProtKB/TrEMBL
      Q3U5A0, Q80TI9
      Related
      ENSMUSP00000084054.6, ENSMUST00000086843.11
      Conserved Domains (5) summary
      cd00204
      Location:80 → 213
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:295 → 336
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:83 → 174
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:40 → 99
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:80 → 109
      ANK; ANK repeat [structural motif]

    2. NM_023046.4 → NP_075533.3  ankyrin repeat and SOCS box protein 1 isoform b

      See identical proteins and their annotated locations for NP_075533.3

      Status: VALIDATED

      Source sequence(s)
      AC109199, AK153774, BU938650
      Consensus CDS
      CCDS35666.1
      UniProtKB/TrEMBL
      G3X9J5, Q9D9S9
      Related
      ENSMUSP00000140731.2, ENSMUST00000188879.2
      Conserved Domains (5) summary
      cd00204
      Location:72 → 205
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:287 → 328
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:75 → 166
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:32 → 91
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:72 → 101
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91467725..91487312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529790.5 → XP_006529853.1  ankyrin repeat and SOCS box protein 1 isoform X2

      UniProtKB/TrEMBL
      S4W6L8
      Related
      ENSMUSP00000140281.2, ENSMUST00000190484.7
      Conserved Domains (3) summary
      COG0666
      Location:21 → 164
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd03720
      Location:194 → 235
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:39 → 72
      ANK; ANK repeat [structural motif]

    2. XM_006529789.3 → XP_006529852.1  ankyrin repeat and SOCS box protein 1 isoform X1

      UniProtKB/TrEMBL
      Q9D9S9
      Conserved Domains (5) summary
      PHA02875
      Location:77 → 263
      PHA02875; ankyrin repeat protein; Provisional
      cd03720
      Location:291 → 332
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:76 → 105
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:79 → 170
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:19 → 105
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV74.1 GenPept UniProtKB/Swiss-Prot:Q9WV74

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