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    Spase25 Spase 25-subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32095, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Spase25provided by FlyBase
    Official Full Name
    Spase 25-subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030306
    Locus tag
    Dmel_CG1751
    See related
    AllianceGenome:FB:FBgn0030306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1571; CG1751; Dmel\CG1751
    Summary
    Predicted to be involved in protein targeting to ER and signal peptide processing. Located in endomembrane system. Is expressed in several structures, including adult heart; dorsal epidermis primordium; embryonic/larval salivary gland; presumptive embryonic/larval system; and proventriculus primordium. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Spase25 in Genome Data Viewer
    Location:
    10B15-10B16; 1-34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11485250..11486566)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11379283..11380599)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4g15 Neighboring gene long non-coding RNA:CR44556 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-like activating enzyme 5 Neighboring gene Death-associated protein kinase related Neighboring gene mir-2492 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the functions of the signal peptidase complex in the midgut of Tribolium castaneum. Guan J, et al. Arch Insect Biochem Physiol, 2018 Mar. PMID 29265467
    2. Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA. Ragheb R, et al. Sci Rep, 2017 Nov 24. PMID 29176735, Free PMC Article
    3. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
    4. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article
    5. TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior. Ng FS, et al. Front Mol Neurosci, 2016. PMID 28066175, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spase 25-subunit
    Names
    CG1751-PA
    CG1751-PB
    CG1751-PC
    SPase 25-subunit
    Spase25-PA
    Spase25-PB
    Spase25-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11485250..11486566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298196.1 → NP_001285125.1  spase 25-subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285125.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY2
      UniProtKB/TrEMBL
      B4F5U4, B4F5V0, B4F5V1
      Conserved Domains (1) summary
      pfam06703
      Location:30 → 183
      SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

    2. NM_132495.3 → NP_572723.1  spase 25-subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY2
      UniProtKB/TrEMBL
      B4F5U4, B4F5V0, B4F5V1
      Related
      FBpp0073355
      Conserved Domains (1) summary
      pfam06703
      Location:30 → 183
      SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

    3. NM_001298195.1 → NP_001285124.1  spase 25-subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285124.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY2
      UniProtKB/TrEMBL
      B4F5U4, B4F5V0, B4F5V1
      Conserved Domains (1) summary
      pfam06703
      Location:30 → 183
      SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4F5U4 B4F5U4
    Q9VYY2.1 Q9VYY2

    Gene LinkOut

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