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    RDH16 retinol dehydrogenase 16 [ Homo sapiens (human) ]

    Gene ID: 8608, updated on 10-Dec-2024

    Summary

    Official Symbol
    RDH16provided by HGNC
    Official Full Name
    retinol dehydrogenase 16provided by HGNC
    Primary source
    HGNC:HGNC:29674
    See related
    Ensembl:ENSG00000139547 MIM:620043; AllianceGenome:HGNC:29674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RODH4; RODH-4; SDR9C8; hRDH-E
    Summary
    Enables all-trans-retinol dehydrogenase (NAD+) activity; androstan-3-alpha,17-beta-diol dehydrogenase activity; and androsterone dehydrogenase activity. Involved in steroid metabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver (RPKM 111.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RDH16 in Genome Data Viewer
    Location:
    12q13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56951431..56957608, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56919300..56925477, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57345215..57351392, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 9C member 7 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene origin of replication ori6 Neighboring gene uncharacterized LOC124902945 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr12.2240 Neighboring gene G protein-coupled receptor 182 Neighboring gene zinc finger and BTB domain containing 39

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    retinol dehydrogenase 16
    Names
    human epidermal retinol dehydrogenase
    microsomal NAD+-dependent retinol dehydrogenase 4
    retinol dehydrogenase 16 (all-trans and 13-cis)
    retinol dehydrogenase 16 (all-trans)
    short chain dehydrogenase/reductase family 9C, member 8
    sterol/retinol dehydrogenase
    NP_001307037.1
    NP_003699.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320108.2NP_001307037.1  retinol dehydrogenase 16 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and initiates translation at an alternate downstream start codon compared to variant 1. The encoded isoform (2) has a shorter, distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB209332, AW449664
      UniProtKB/TrEMBL
      Q59FX7
      Conserved Domains (1) summary
      cl21454
      Location:46160
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_003708.5NP_003699.3  retinol dehydrogenase 16 isoform 1

      See identical proteins and their annotated locations for NP_003699.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB209332, AC026120, AF057034, AW449664
      Consensus CDS
      CCDS41797.1
      UniProtKB/Swiss-Prot
      O75452, Q9UNV2
      Related
      ENSP00000381206.3, ENST00000398138.5
      Conserved Domains (2) summary
      pfam00106
      Location:30218
      adh_short; short chain dehydrogenase
      cl21454
      Location:30305
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      56951431..56957608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      56919300..56925477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)