CD63 CD63 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD63provided by HGNC
Official Full Name: CD63 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1692
See related: Ensembl:ENSG00000135404 MIM:155740; AllianceGenome:HGNC:1692
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AD1; MLA1; ME491; HOP-26; OMA81H; Pltgp40; TSPAN30
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Expression: Ubiquitous expression in fat (RPKM 184.8), colon (RPKM 181.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (55723535..55730041, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (55690169..55696675, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (56117319..56123825, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies.
Title: Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies.
The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets.
Title: The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets.
Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles.
Title: Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles.
Lack of involvement of CD63 and CD9 tetraspanins in the extracellular vesicle content delivery process.
Title: Lack of involvement of CD63 and CD9 tetraspanins in the extracellular vesicle content delivery process.
LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection.
Title: LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection.
Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma.
Title: Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma.
CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma.
Title: CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma.
A potential target gene CD63 for different degrees of intervertebral disc degeneration.
Title: A potential target gene CD63 for different degrees of intervertebral disc degeneration.
CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance.
Title: CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance.
Activated steady status and distinctive FcepsilonRI-mediated responsiveness in basophils of atopic dermatitis.
Title: Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 LAI replication requires CD63 expression as knockdown with shRNA decreases viral production in HeLa cells	PubMed
siRNA knockdown of CD63 in U1/HIV-1 cells (chronically infected monocytoid cells harboring 2 integrated copies of HIV provirus per cell) decreases CA (p24) levels in supernatants but does not affect intracellular CA (p24) levels	PubMed
siRNA knockdown of CD63 decreases CCR5-tropic (ADA) and dual-tropic (89.6) pseudotyped virus (luciferase reporter HIV backbone presumed) infection of MDMs, yet does not affect MLV- and VSV-pseudotyped virus infection, as measured by luciferase activity	PubMed
siRNA knockdown of CD63 decreases HIV production from peripheral blood lymphocytes and dendritic cells as measured by supernatant CA (p24) levels	PubMed
siRNA knockdown of CD63 decreases HIV production from monocyte-derived macrophages (MDMs) infected with HIV-1 (SX strain) at a low multiplicity of infection (MOI= 0.02)	PubMed
Knockdown of CD63 by siRNA inhibits HIV-1 infection and replication in human CD4+ T cells, macrophages, and peripheral blood lymphocytes	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	CD63 enhances HIV-1 gp120/gp41-mediated entry in human macrophages	PubMed
	env	HIV-1 Gag, CA, and gp120 proteins co-localizes with CD63 and acetylcholinesterase (ACHE)-associated exosomes from supernatants of HIV-1 expressing cells. The 5' end of the Gag p17 open reading frame is sufficient for HIV-1 RNA exosome incorporation	PubMed
	env	Recruitment of Env to tetraspanin-enriched micro domains (TEMs) is required for cell-cell fusion repression by CD9 and CD63	PubMed
	env	Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 Env co-localizes with CD63 in HIV-1 infected CD4+ T cells	PubMed
	env	Recruitment of Env to tetraspanin-enriched micro domains (TEMs) is required for cell-cell fusion repression by CD9 and CD63	PubMed
	env	DLG1 knockdown is associated with the redistribution and colocalization of Env toward CD63 and CD82 positive vesicle-like structures	PubMed
	env	In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding	PubMed
	env	CD63 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 co-localizes predominantly with CD63 at the virological synapse of Jurkat cells	PubMed
	env	CD63 enhances HIV-1 gp120/gp41-mediated entry in human macrophages	PubMed
	env	Recruitment of Env to tetraspanin-enriched microdomains (TEMs) is required for cell-cell fusion repression by CD9 and CD63	PubMed
	env	Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection	PubMed
Nef	nef	HIV-1 Nef induces release of CD63 (MAL-dependent exosome marker) from Jurkat T cells transfected with DNA constructs coding for Nef-GFP	PubMed
	nef	Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD63 (TSPAN30)	PubMed
	nef	HIV-1 Nef targets CD4 to CD63-containing lysosomes for Nef-induced degradation of CD4, which requires the VPS4-mediated ESCRT machinery	PubMed
	nef	HIV-1 Nef increases the production of exosomes, which form in the late endosomes and co-localizes with the late endosomal marker CD63 in SupT cells	PubMed
	nef	HIV-1 Nef increases the production of exosomes, co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells	PubMed
Pr55(Gag)	gag	Co-localization of HIV-1 Gag virus-like particles in THP-1/CD169YF cells is reduced within CD81+ compartments, but enhanced within CD63+ or LAMP1+ compartments	PubMed
	gag	HIV-1 Gag proteins co-localize with CD63 and CD81 in intracellular exosomes	PubMed
	gag	HIV-1 Gag, CA, and gp120 proteins co-localizes with CD63 and acetylcholinesterase (ACHE)-associated exosomes from supernatants of HIV-1 expressing cells. The 5' end of the Gag p17 open reading frame is sufficient for HIV-1 RNA exosome incorporation	PubMed
	gag	Tetherin co-localizes with HIV-1 Gag in CD81- and CD63-enriched intracellular virus-containing compartments in macrophages, and that a separate population of tetherin is located in the TGN	PubMed
	gag	The budding defect of p6-deficient HIV-1 Gag is caused primarily by C-terminal exposure of p1. The p1 domain of p6-deficient Gag acts as an inhibitory budding signal by blocking the interaction of Gag with CD63 and VPS4B	PubMed
	gag	Env-mediated cell-cell fusion repression by CD9 and CD63 requires the presence of HIV-1 Gag	PubMed
	gag	DLG1 knockdown is associated with the redistribution and colocalization of Gag toward CD63 and CD82 positive vesicle-like structures	PubMed
	gag	HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched micro domains	PubMed
	gag	A dileucine-like motif (residues 321-322) in HIV-1 Gag regulates the assembly of Gag into CD63-positive multivesicular bodies	PubMed
	gag	In human macrophages, HIV-1 Gag proteins co-localize with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments	PubMed
Tat	tat	siRNA-mediated CD63 down regulation reduces production of the early HIV protein Tat in both macrophages and a CD4(+) cell line	PubMed
Vpu	vpu	Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD63 (TSPAN30)	PubMed
capsid	gag	HIV-1 Gag colocalizes with CD63 in U1/HIV-1 cells (chronically infected monocytoid cells harboring 2 integrated copies of HIV provirus per cell)	PubMed
	gag	siRNA knockdown of CD63 in U1/HIV-1 cells (chronically infected monocytoid cells harboring 2 integrated copies of HIV provirus per cell) affects CA (p24) levels in supernatants (decreases) but not intracellular CA (p24) levels	PubMed
	gag	HIV-1 Gag, CA, and gp120 proteins co-localizes with CD63 and acetylcholinesterase (ACHE)-associated exosomes from supernatants of HIV-1 expressing cells. The 5' end of the Gag p17 open reading frame is sufficient for HIV-1 RNA exosome incorporation	PubMed
	gag	CD63 silencing inhibits production of the late protein CA p24 in early HIV-1 replication events in both macrophages and a CD4(+) cell line	PubMed
	gag	In human macrophages, HIV-1 Capsid (p24) co-localizes with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments	PubMed
matrix	gag	HIV-1 Gag colocalizes with CD63 in U1/HIV-1 cells (chronically infected monocytoid cells harboring 2 integrated copies of HIV provirus per cell)	PubMed
	gag	In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93515 (e-PCR)
- UniSTS:88736

RK1421_1422 (e-PCR)
- UniSTS:14753

STS-AA035150 (e-PCR)
- UniSTS:66783

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigment granule maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule membrane	TAS Traceable Author Statement more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endosome lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	HDA more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	HDA more info	PubMed
located_in multivesicular body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body, internal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in platelet dense granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CD63 antigen

Names: AD1 antigen; CD63 antigen (melanoma 1 antigen); granulophysin; limp1; melanoma-associated antigen ME491; melanoma-associated antigen MLA1; ocular melanoma-associated antigen; tetraspanin-30; tspan-30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008347.1 RefSeqGene

Range

5118..8804

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001257389.2 → NP_001244318.1 CD63 antigen isoform A

See identical proteins and their annotated locations for NP_001244318.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 3-5, and 10-15 all encode the same isoform (A).

Source sequence(s)

AC009779, BU960599, CB128206, CD250685, CN296813

Consensus CDS

CCDS8890.1

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0

Related

ENSP00000447730.1, ENST00000549117.5

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family
NM_001257390.2 → NP_001244319.1 CD63 antigen isoform A

See identical proteins and their annotated locations for NP_001244319.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 3-5, and 10-15 all encode the same isoform (A).

Source sequence(s)

AC009779, BG478842, BU960599

Consensus CDS

CCDS8890.1

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0

Related

ENSP00000393502.3, ENST00000420846.7

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family
NM_001257391.2 → NP_001244320.1 CD63 antigen isoform A

See identical proteins and their annotated locations for NP_001244320.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 5' UTR segment, compared to variant 1. Variants 1, 3-5, and 10-15 all encode the same isoform (A).

Source sequence(s)

AC009779, AL582859, BU960599

Consensus CDS

CCDS8890.1

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0

Related

ENSP00000449337.1, ENST00000552692.5

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family
NM_001257392.1 → NP_001244321.1 CD63 antigen isoform C

See identical proteins and their annotated locations for NP_001244321.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (C) lacks an internal segment, compared to isoform A.

Source sequence(s)

AF508304, BU960599, CN484590

Consensus CDS

CCDS58243.1

UniProtKB/TrEMBL

W6A4U0

Related

ENSP00000446807.1, ENST00000552754.5

Conserved Domains (2) summary

cd03166
Location:82 → 180

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:28 → 208

Tetraspannin; Tetraspanin family
NM_001257400.2 → NP_001244329.1 CD63 antigen isoform D precursor

See identical proteins and their annotated locations for NP_001244329.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains a distinct 5' UTR exon and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (D) has a shorter N-terminus, compared to isoform A. Variants 8 and 9 encode the same isoform D.

Source sequence(s)

AC009779, BC013017, BG766593, BU960599

Consensus CDS

CCDS58242.1

UniProtKB/TrEMBL

F8VV56

Related

ENSP00000447356.1, ENST00000546939.5

Conserved Domains (1) summary

cd03166
Location:23 → 121

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
NM_001257401.2 → NP_001244330.1 CD63 antigen isoform D precursor

See identical proteins and their annotated locations for NP_001244330.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) contains a distinct 5' UTR exon and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (D) has a shorter N-terminus, compared to isoform A. Variants 8, 9, and 16 all encode the same isoform (D).

Source sequence(s)

AC009779, BQ434569, BU190521, BU960599

Consensus CDS

CCDS58242.1

UniProtKB/TrEMBL

F8VV56

Related

ENSP00000448091.1, ENST00000550776.5

Conserved Domains (1) summary

cd03166
Location:23 → 121

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
NM_001267698.2 → NP_001254627.1 CD63 antigen isoform A

See identical proteins and their annotated locations for NP_001254627.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 3-5, and 10-15 all encode the same isoform (A).

Source sequence(s)

AA583189, AC009779, BC002349, BU167765

Consensus CDS

CCDS8890.1

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0

Related

ENSP00000449281.1, ENST00000552164.5

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family
NM_001413281.1 → NP_001400210.1 CD63 antigen isoform A

Status: REVIEWED

Source sequence(s)

AC009779

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0
NM_001413282.1 → NP_001400211.1 CD63 antigen isoform A

Status: REVIEWED

Source sequence(s)

AC009779

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0
NM_001413283.1 → NP_001400212.1 CD63 antigen isoform A

Status: REVIEWED

Source sequence(s)

AC009779

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0
NM_001413284.1 → NP_001400213.1 CD63 antigen isoform A

Status: REVIEWED

Source sequence(s)

AC009779

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0
NM_001413285.1 → NP_001400214.1 CD63 antigen isoform A

Status: REVIEWED

Source sequence(s)

AC009779

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0
NM_001413286.1 → NP_001400215.1 CD63 antigen isoform D

Status: REVIEWED

Source sequence(s)

AC009779

UniProtKB/TrEMBL

F8VV56

Related

ENSP00000449654.1, ENST00000548160.5
NM_001413287.1 → NP_001400216.1 CD63 antigen isoform E

Status: REVIEWED

Source sequence(s)

AC009779

UniProtKB/TrEMBL

W6A4U0
NM_001413288.1 → NP_001400217.1 CD63 antigen isoform F

Status: REVIEWED

Source sequence(s)

AC009779

UniProtKB/TrEMBL

W6A4U0
NM_001780.6 → NP_001771.1 CD63 antigen isoform A

See identical proteins and their annotated locations for NP_001771.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (A). Variants 1, 3-5, and 10-15 all encode the same isoform (A).

Source sequence(s)

AC009779, BU960599, EB386351

Consensus CDS

CCDS8890.1

UniProtKB/Swiss-Prot

F8VZE2, P08962, Q5TZP3, Q8N6Z9, Q9UCG6

UniProtKB/TrEMBL

W6A4U0

Related

ENSP00000257857.4, ENST00000257857.9

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

55723535..55730041 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

55690169..55696675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001040034.1: Suppressed sequence

Description

NM_001040034.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.