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    SATL1 spermidine/spermine N1-acetyl transferase like 1 [ Homo sapiens (human) ]

    Gene ID: 340562, updated on 17-Jun-2024

    Summary

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    Official Symbol
    SATL1provided by HGNC
    Official Full Name
    spermidine/spermine N1-acetyl transferase like 1provided by HGNC
    Primary source
    HGNC:HGNC:27992
    See related
    Ensembl:ENSG00000184788 AllianceGenome:HGNC:27992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable N-acetyltransferase activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 7.8), fat (RPKM 5.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SATL1 in Genome Data Viewer
    Location:
    Xq21.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (85092284..85243779, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (83521243..83672628, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (84347290..84498785, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene testis expressed 16, pseudogene Neighboring gene SET pseudogene 4 Neighboring gene ubiquitin conjugating enzyme E2 D N-terminal like (pseudogene) Neighboring gene apolipoprotein O like Neighboring gene uncharacterized LOC101928128 Neighboring gene zinc finger protein 711 Neighboring gene POF1B actin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H. Imai H, et al. Oncol Rep, 2014 Mar. PMID 24378760, Free PMC Article
    2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    3. Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex. Schaefer KN, et al. Mol Biol Cell, 2020 May 1. PMID 32129710, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables diamine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermidine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in spermidine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spermidine/spermine N(1)-acetyltransferase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016590.2 RefSeqGene

      Range
      139812..156494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012980.2 → NP_001012998.2  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BC043215, Z99571
      Consensus CDS
      CCDS35343.2
      UniProtKB/Swiss-Prot
      Q86VE3
      Related
      ENSP00000425421.1, ENST00000509231.1
      Conserved Domains (1) summary
      pfam03157
      Location:81 → 508
      Glutenin_hmw; High molecular weight glutenin subunit

    2. NM_001367857.2 → NP_001354786.1  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC003001, Z83820, Z99571
      Consensus CDS
      CCDS94638.1
      UniProtKB/Swiss-Prot
      A0A2R8Y5C1, A0AVK7, E9PB72, Q5H8V9, Q86VE3
      Related
      ENSP00000494345.1, ENST00000644105.2
      Conserved Domains (2) summary
      pfam00583
      Location:543 → 668
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam03157
      Location:109 → 541
      Glutenin_hmw; High molecular weight glutenin subunit

    3. NM_001367858.2 → NP_001354787.1  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC003001, Z83820, Z99571
      Consensus CDS
      CCDS94637.1
      UniProtKB/TrEMBL
      A0A2R8YFQ0
      Related
      ENSP00000495329.1, ENST00000646235.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      85092284..85243779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442081.1 → XP_047298037.1  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8Y5C1, A0AVK7, E9PB72, Q5H8V9, Q86VE3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      83521243..83672628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326989.1 → XP_054182964.1  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8Y5C1, A0AVK7, E9PB72, Q5H8V9, Q86VE3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001163541.1: Suppressed sequence

      Description
      NM_001163541.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VE3.4 GenPept UniProtKB/Swiss-Prot:Q86VE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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