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    SPACA5 sperm acrosome associated 5 [ Homo sapiens (human) ]

    Gene ID: 389852, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SPACA5provided by HGNC
    Official Full Name
    sperm acrosome associated 5provided by HGNC
    Primary source
    HGNC:HGNC:31353
    See related
    Ensembl:ENSG00000171489 MIM:300593; AllianceGenome:HGNC:31353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYC5; LYZL5; SLLP2; SLLP-X; UNQ6288; PNPK6288
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in extracellular region. Predicted to be active in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 3.7) See more
    Orthologs
    mouse all
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    Genomic context

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    See SPACA5 in Genome Data Viewer
    Location:
    Xp11.23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (48004336..48009733)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (47414513..47419909)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47863734..47869130)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 57 Neighboring gene zinc finger protein 81 Neighboring gene CRISPRi-FlowFISH-validated HDAC6 regulatory element 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29599 Neighboring gene zinc finger protein 182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20813 Neighboring gene ZNF630 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:47931149-47931345 Neighboring gene small nucleolar RNA U13 Neighboring gene zinc finger protein 630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. Chen YT, et al. Genes Chromosomes Cancer, 2006 Apr. PMID 16382448
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sperm acrosome-associated protein 5
    Names
    lysozyme-like protein 5
    sperm lysozyme-like protein 2
    sperm-specific lysozyme-like protein X
    testicular tissue protein Li 113
    NP_001381227.1
    NP_995328.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394298.1 → NP_001381227.1  sperm acrosome-associated protein 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC244636
      Consensus CDS
      CCDS14286.1
      UniProtKB/Swiss-Prot
      Q6UWD1, Q96QH8
      UniProtKB/TrEMBL
      A0A140VJN7
      Related
      ENSP00000366139.3, ENST00000376940.4
      Conserved Domains (1) summary
      cd16897
      Location:22 → 147
      LYZ_C; C-type lysozyme

    2. NM_205856.3 → NP_995328.2  sperm acrosome-associated protein 5 precursor

      See identical proteins and their annotated locations for NP_995328.2

      Status: VALIDATED

      Source sequence(s)
      AC244636
      Consensus CDS
      CCDS14286.1
      UniProtKB/Swiss-Prot
      Q6UWD1, Q96QH8
      UniProtKB/TrEMBL
      A0A140VJN7
      Related
      ENSP00000305847.5, ENST00000304355.9
      Conserved Domains (1) summary
      cd16897
      Location:22 → 147
      LYZ_C; C-type lysozyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      48004336..48009733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      47414513..47419909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96QH8.1 GenPept UniProtKB/Swiss-Prot:Q96QH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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