U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TAS2R14 taste 2 receptor member 14 [ Homo sapiens (human) ]

    Gene ID: 50840, updated on 10-Dec-2024

    Summary

    Official Symbol
    TAS2R14provided by HGNC
    Official Full Name
    taste 2 receptor member 14provided by HGNC
    Primary source
    HGNC:HGNC:14920
    See related
    Ensembl:ENSG00000212127 MIM:604790; AllianceGenome:HGNC:14920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRB1; T2R14
    Summary
    This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TAS2R14 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10937410..10939263, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10810447..10812300, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11090009..11091862, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene taste 2 receptor member 13 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:11094509-11095708 Neighboring gene proline rich protein HaeIII subfamily 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:11127502-11128380 Neighboring gene taste 2 receptor member 15 pseudogene Neighboring gene taste 2 receptor member 50

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough PRH1-TAS2R14

    Readthrough gene: PRH1-TAS2R14, Included gene: PRH1

    Clone Names

    • MGC125491, MGC125492

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables bitter taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables taste receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables taste receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    taste receptor type 2 member 14
    Names
    taste receptor, family B, member 1
    taste receptor, type 2, member 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023922.2NP_076411.1  taste receptor type 2 member 14

      See identical proteins and their annotated locations for NP_076411.1

      Status: REVIEWED

      Source sequence(s)
      AC006518
      Consensus CDS
      CCDS8637.1
      UniProtKB/Swiss-Prot
      Q645X3, Q9NYV8
      UniProtKB/TrEMBL
      Q50KP5
      Related
      ENSP00000441949.1, ENST00000537503.2
      Conserved Domains (1) summary
      cd15019
      Location:8295
      7tm_TAS2R14-like; mammalian taste receptor 2, subtype 14, member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10937410..10939263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      136116..137969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      136116..137969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10810447..10812300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)