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    ZFP62 ZFP62 zinc finger protein [ Homo sapiens (human) ]

    Gene ID: 643836, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZFP62provided by HGNC
    Official Full Name
    ZFP62 zinc finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:23241
    See related
    Ensembl:ENSG00000196670 MIM:610281; AllianceGenome:HGNC:23241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZET; ZNF755
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: Annotation of ZFP62 was placed on AC016572.6 on NCBI's annotation 36.3. This clone has been determined to be redundant, so the annotation was merged with the location on the assembled chromosome. [02 Mar 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.7), lymph node (RPKM 4.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZFP62 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180826870..180861276, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181399916..181417629, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180274611..180288276, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily Y member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180212035-180212946 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180212947-180213857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180224505-180225006 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr5:180229118-180229825 and GRCh37_chr5:180229826-180230532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180231240-180231945 Neighboring gene alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23771 Neighboring gene Sharpr-MPRA regulatory region 14850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16777 Neighboring gene long intergenic non-protein coding RNA 847 Neighboring gene Sharpr-MPRA regulatory region 9005 Neighboring gene hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180288413-180289319 Neighboring gene uncharacterized LOC124901155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23773 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180334710-180335266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180335267-180335821 Neighboring gene butyrophilin like 8 Neighboring gene ribosomal protein S29 pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Differentiation dependent expression in muscle cells of ZT3, a novel zinc finger factor differentially expressed in embryonic and adult tissues. Polimeni M, et al. Mech Dev, 1996 Jan. PMID 8808410
    2. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. Yu LR, et al. J Proteome Res, 2007 Nov. PMID 17924679
    3. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
    4. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk. Lukinović V, et al. Cancer Discov, 2022 Sep 2. PMID 35819319, Free PMC Article
    5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11344, FLJ34057, FLJ34231, FLJ58781, FLJ59694, MGC176438, DKFZp667F2013

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 62 homolog
    Names
    zfp-62

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172638.2 → NP_001166109.1  zinc finger protein 62 homolog isoform 2

      See identical proteins and their annotated locations for NP_001166109.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS54955.1
      UniProtKB/Swiss-Prot
      B4DIP6, B4E0N3, B5MDX6, B7ZVZ2, B9EIP6, E9PFT8, J3QTA9, Q8NB50
      Related
      ENSP00000423820.1, ENST00000502412.2
      Conserved Domains (2) summary
      COG5048
      Location:447 → 860
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001377939.1 → NP_001364868.1  zinc finger protein 62 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS47357.2
      Conserved Domains (2) summary
      COG5048
      Location:414 → 827
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001377940.1 → NP_001364869.1  zinc finger protein 62 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS47357.2
      Conserved Domains (2) summary
      COG5048
      Location:414 → 827
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001377941.1 → NP_001364870.1  zinc finger protein 62 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS47357.2
      Conserved Domains (2) summary
      COG5048
      Location:414 → 827
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001377942.1 → NP_001364871.1  zinc finger protein 62 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS47357.2
      Conserved Domains (2) summary
      COG5048
      Location:414 → 827
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001377943.1 → NP_001364872.1  zinc finger protein 62 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022413
      UniProtKB/Swiss-Prot
      B4DIP6, B4E0N3, B5MDX6, B7ZVZ2, B9EIP6, E9PFT8, J3QTA9, Q8NB50
      Conserved Domains (2) summary
      COG5048
      Location:447 → 860
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001377944.1 → NP_001364873.1  zinc finger protein 62 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022413
      Conserved Domains (2) summary
      COG5048
      Location:363 → 776
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001377945.1 → NP_001364874.1  zinc finger protein 62 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC022413
      Conserved Domains (2) summary
      COG5048
      Location:330 → 743
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_152283.5 → NP_689496.4  zinc finger protein 62 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS47357.2
      UniProtKB/Swiss-Prot
      Q8NB50
      Related
      ENSP00000426193.1, ENST00000512132.5
      Conserved Domains (2) summary
      COG5048
      Location:414 → 827
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      180826870..180861276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417504.1 → XP_047273460.1  zinc finger protein 62 homolog isoform X9

    2. XM_047417501.1 → XP_047273457.1  zinc finger protein 62 homolog isoform X5

    3. XM_047417502.1 → XP_047273458.1  zinc finger protein 62 homolog isoform X7

    4. XM_017009716.3 → XP_016865205.1  zinc finger protein 62 homolog isoform X3

    5. XM_017009718.3 → XP_016865207.1  zinc finger protein 62 homolog isoform X4

    6. XM_047417499.1 → XP_047273455.1  zinc finger protein 62 homolog isoform X1

    7. XM_047417500.1 → XP_047273456.1  zinc finger protein 62 homolog isoform X2

    8. XM_047417503.1 → XP_047273459.1  zinc finger protein 62 homolog isoform X8

    9. XM_017009719.3 → XP_016865208.1  zinc finger protein 62 homolog isoform X6

    RNA

    1. XR_007058623.1 RNA Sequence

    2. XR_007058622.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      181399916..181417629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353106.1 → XP_054209081.1  zinc finger protein 62 homolog isoform X5

    2. XM_054353108.1 → XP_054209083.1  zinc finger protein 62 homolog isoform X7

    3. XM_054353104.1 → XP_054209079.1  zinc finger protein 62 homolog isoform X3

    4. XM_054353105.1 → XP_054209080.1  zinc finger protein 62 homolog isoform X4

    5. XM_054353101.1 → XP_054209076.1  zinc finger protein 62 homolog isoform X1

    6. XM_054353103.1 → XP_054209078.1  zinc finger protein 62 homolog isoform X2

    7. XM_054353109.1 → XP_054209084.1  zinc finger protein 62 homolog isoform X8

    8. XM_054353102.1 → XP_054209077.1  zinc finger protein 62 homolog isoform X10

    9. XM_054353107.1 → XP_054209082.1  zinc finger protein 62 homolog isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NB50.3 GenPept UniProtKB/Swiss-Prot:Q8NB50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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