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    ZNF32 zinc finger protein 32 [ Homo sapiens (human) ]

    Gene ID: 7580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZNF32provided by HGNC
    Official Full Name
    zinc finger protein 32provided by HGNC
    Primary source
    HGNC:HGNC:13095
    See related
    Ensembl:ENSG00000169740 MIM:194539; AllianceGenome:HGNC:13095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX30; ZNF637; Zfp637
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 6.7), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF32 in Genome Data Viewer
    Location:
    10q11.21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (43643862..43648881, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (44524781..44529800, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (44139310..44144329, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2335 Neighboring gene zinc finger protein 485 Neighboring gene uncharacterized LOC124902416 Neighboring gene ZNF32 antisense RNA 3 Neighboring gene ribosomal protein L21 pseudogene 88 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:44141084-44142283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2336 Neighboring gene ZNF32 antisense RNA 1 Neighboring gene ZNF32 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:44162766-44162945 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2337 Neighboring gene uncharacterized LOC124902417 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12372 Neighboring gene SPRING1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells. Drew PD, et al. J Neurovirol, 1997 Dec. PMID 9475118
    2. ZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death. Li Y, et al. Sci Rep, 2015 Mar 19. PMID 25786368, Free PMC Article
    3. Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. Cannizzaro LA, et al. Hum Genet, 1993 May. PMID 8500793
    4. Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription. Li Y, et al. Cell Death Dis, 2018 Nov 26. PMID 30478301, Free PMC Article
    5. ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma. Li K, et al. Cancer Lett, 2019 Feb 1. PMID 30439540

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF32 prevents the activation of cancer-associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer.
      Title: ZNF32 prevents the activation of cancer-associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer.
    2. ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway.
      Title: ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway.
    3. We conclude that ZNF32 can engage GPER/ERK signalling and confer breast cancer stem cell-like properties, which may indicate poor prognosis of breast cancer patients. ZNF32 and GPER targeted therapies might provide new solutions for breast cancer treatment.
      Title: Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription.
    4. ZNF32 contributes to anoikis resistance by maintaining redox homeostasis and activating Src/FAK signaling in HepG2 cells.
      Title: ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma.
    5. ZNF32 was found to directly bind to the TGF-betaR2 (transforming growth factor-beta receptor 2) promoter to promote its expression.
      Title: ZNF32 contributes to the induction of multidrug resistance by regulating TGF-β receptor 2 signaling in lung adenocarcinoma.
    6. Sp1-ZNF32-C1QBP axis protects against oxidative stress/apoptosis in hepatocellular carcinoma cells.
      Title: ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription.
    7. ZNF32 acts as an effective autophagy inhibitor to protect breast cancer cells from excessive stimulus-autophagy-induced cell death.
      Title: ZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 32
    Names
    C2H2-546
    zinc finger protein 32 (KOX 30)
    zinc finger protein KOX30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005368.3 → NP_001005368.1  zinc finger protein 32 isoform a

      See identical proteins and their annotated locations for NP_001005368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC022842, HY045180
      Consensus CDS
      CCDS7206.1
      UniProtKB/Swiss-Prot
      P17041, Q92951
      Related
      ENSP00000379143.1, ENST00000395797.1
      Conserved Domains (2) summary
      COG5048
      Location:47 → 237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:79 → 99
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001324164.2 → NP_001311093.1  zinc finger protein 32 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) and variant 4 both encode the same isoform (b).
      Source sequence(s)
      AL645634
      Conserved Domains (2) summary
      COG5048
      Location:51 → 241
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:83 → 103
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001324165.2 → NP_001311094.1  zinc finger protein 32 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) and variant 3 both encode the same isoform (b).
      Source sequence(s)
      BC022842, HY045180, HY148951
      UniProtKB/Swiss-Prot
      P17041
      Conserved Domains (2) summary
      COG5048
      Location:51 → 241
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:83 → 103
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001324166.2 → NP_001311095.1  zinc finger protein 32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 6 and 7, encodes isoform c.
      Source sequence(s)
      AL645634
      Conserved Domains (2) summary
      COG5048
      Location:22 → 212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:54 → 74
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001324167.2 → NP_001311096.1  zinc finger protein 32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 5 and 7, encodes isoform c.
      Source sequence(s)
      AL645634
      Conserved Domains (2) summary
      COG5048
      Location:22 → 212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:54 → 74
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001324168.2 → NP_001311097.1  zinc finger protein 32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform c.
      Source sequence(s)
      BC022842, HY045180
      UniProtKB/Swiss-Prot
      P17041
      Conserved Domains (2) summary
      COG5048
      Location:22 → 212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:54 → 74
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_006973.3 → NP_008904.1  zinc finger protein 32 isoform a

      See identical proteins and their annotated locations for NP_008904.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the more frequently occurring variant. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL645634, BC022842, BG477527
      Consensus CDS
      CCDS7206.1
      UniProtKB/Swiss-Prot
      P17041, Q92951
      Related
      ENSP00000363556.2, ENST00000374433.7
      Conserved Domains (2) summary
      COG5048
      Location:47 → 237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:79 → 99
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      43643862..43648881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      44524781..44529800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17041.2 GenPept UniProtKB/Swiss-Prot:P17041

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