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    LYZL1 lysozyme like 1 [ Homo sapiens (human) ]

    Gene ID: 84569, updated on 27-Nov-2024

    Summary

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    Official Symbol
    LYZL1provided by HGNC
    Official Full Name
    lysozyme like 1provided by HGNC
    Primary source
    HGNC:HGNC:30502
    See related
    Ensembl:ENSG00000120563 AllianceGenome:HGNC:30502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYC2; LYZD1; KAAG648; PRO1278; bA534G20.1
    Summary
    Predicted to enable lysozyme activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 12.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See LYZL1 in Genome Data Viewer
    Location:
    10p12.1-p11.23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (29289070..29318328)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (29320734..29350003)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (29577999..29600161)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984171 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:29429294-29429794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:29429795-29430295 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:29448375-29449050 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:29495743-29495973 Neighboring gene uncharacterized LOC105376472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3194 Neighboring gene OCT4 hESC enhancer GRCh37_chr10:29591323-29591859 Neighboring gene uncharacterized LOC124902400 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:29633052-29634251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:29655033-29655534 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:29655751-29656950 Neighboring gene uncharacterized LOC107984217 Neighboring gene uncharacterized LOC105376473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:29683525-29684039 Neighboring gene uncharacterized LOC105376474

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Wu JH, et al. Circ Cardiovasc Genet, 2013 Apr. PMID 23362303, Free PMC Article
    2. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Uhl GR, et al. Arch Gen Psychiatry, 2008 Jun. PMID 18519826, Free PMC Article
    3. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    4. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33408

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme-like protein 1
    Names
    lysozyme D1
    NP_115906.4
    XP_005252684.1
    XP_016872280.1
    XP_054222932.1
    XP_054222933.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032517.6 → NP_115906.4  lysozyme-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AI393331, AL158167, BC021730, BF057063, BG209290, BP369317
      Consensus CDS
      CCDS31174.2
      UniProtKB/Swiss-Prot
      Q5T921, Q6UWQ5, Q8WW16
      Related
      ENSP00000498092.1, ENST00000649382.2
      Conserved Domains (1) summary
      cd00119
      Location:20 → 143
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      29289070..29318328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252627.4 → XP_005252684.1  lysozyme-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A080YUZ8
      Related
      ENSP00000364650.3, ENST00000375500.8
      Conserved Domains (1) summary
      cd00119
      Location:66 → 172
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    2. XM_017016791.2 → XP_016872280.1  lysozyme-like protein 1 isoform X2

    RNA

    1. XR_428650.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      29320734..29350003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366957.1 → XP_054222932.1  lysozyme-like protein 1 isoform X1

    2. XM_054366958.1 → XP_054222933.1  lysozyme-like protein 1 isoform X2

    RNA

    1. XR_008488300.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWQ5.2 GenPept UniProtKB/Swiss-Prot:Q6UWQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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