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    SLC16A13 solute carrier family 16 member 13 [ Homo sapiens (human) ]

    Gene ID: 201232, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SLC16A13provided by HGNC
    Official Full Name
    solute carrier family 16 member 13provided by HGNC
    Primary source
    HGNC:HGNC:31037
    See related
    Ensembl:ENSG00000174327 AllianceGenome:HGNC:31037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT13
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver (RPKM 11.1), kidney (RPKM 6.1) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC16A13 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7036015..7040117)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6936666..6940776)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6939334..6943436)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47316 Neighboring gene mir-497-195 cluster host gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8081 Neighboring gene microRNA 497 Neighboring gene BCL6B transcription repressor Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6938773-6939273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8083 Neighboring gene uncharacterized LOC124903909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8085 Neighboring gene solute carrier family 16 member 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11599 Neighboring gene C-type lectin domain containing 10A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Association between the rs312457 Genotype of the SLC16a13 Gene and Diabetes Mellitus in a Chinese Population. Zheng H, et al. Comput Math Methods Med, 2021. PMID 34257700, Free PMC Article
    2. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. SIGMA Type 2 Diabetes Consortium, et al. Nature, 2014 Feb 6. PMID 24390345, Free PMC Article
    3. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Halestrap AP, et al. Pflugers Arch, 2004 Feb. PMID 12739169
    4. Genome-wide association study identifies three novel loci for type 2 diabetes. Hara K, et al. Hum Mol Genet, 2014 Jan 1. PMID 23945395
    5. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Association between the rs312457 Genotype of the SLC16a13 Gene and Diabetes Mellitus in a Chinese Population.
      Title: The Association between the rs312457 Genotype of the SLC16a13 Gene and Diabetes Mellitus in a Chinese Population.
    2. Data identified three new loci for type 2 diabetes with genome-wide significance: MIR129-LEP, GPSM1 and SLC16A13.
      Title: Genome-wide association study identifies three novel loci for type 2 diabetes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel loci for type 2 diabetes.
    EBI GWAS Catalog
    Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 13
    Names
    MCT 13
    monocarboxylic acid transporter 13
    solute carrier family 16 (monocarboxylic acid transporters), member 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201566.3 → NP_963860.1  monocarboxylate transporter 13

      See identical proteins and their annotated locations for NP_963860.1

      Status: VALIDATED

      Source sequence(s)
      AC040977, BC142618
      Consensus CDS
      CCDS11085.1
      UniProtKB/Swiss-Prot
      A3KMG3, A5PKU5, Q2VP92, Q7RTY0
      Related
      ENSP00000309751.6, ENST00000308027.7
      Conserved Domains (3) summary
      cd06174
      Location:14 → 392
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:21 → 357
      MFS_1; Major Facilitator Superfamily
      pfam11371
      Location:369 → 419
      DUF3172; Protein of unknown function (DUF3172)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7036015..7040117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      6936666..6940776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7RTY0.1 GenPept UniProtKB/Swiss-Prot:Q7RTY0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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