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    UCN3 urocortin 3 [ Homo sapiens (human) ]

    Gene ID: 114131, updated on 9-Dec-2024

    Summary

    Official Symbol
    UCN3provided by HGNC
    Official Full Name
    urocortin 3provided by HGNC
    Primary source
    HGNC:HGNC:17781
    See related
    Ensembl:ENSG00000178473 MIM:605901; AllianceGenome:HGNC:17781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCP; SPC; UCNIII
    Summary
    This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
    Expression
    Biased expression in duodenum (RPKM 4.8), small intestine (RPKM 3.4) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UCN3 in Genome Data Viewer
    Location:
    10p15.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (5364966..5374692)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (5366734..5377963)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5406929..5416655)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4527 Neighboring gene aldo-keto reductase family 1 member C7, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:5333150-5334349 Neighboring gene ribosomal protein L26 pseudogene 28 Neighboring gene MPRA-validated peak854 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr10:5380335-5380511 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:5427032-5427650 Neighboring gene tubulin alpha like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2079 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_13203 Neighboring gene neuroepithelial cell transforming 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_13225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2080

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119002

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables corticotropin-releasing hormone receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables corticotropin-releasing hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables corticotropin-releasing hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in varicosity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    urocortin-3
    Names
    prepro-urocortin 3
    stresscopin
    ucn III
    urocortin III

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053049.4NP_444277.2  urocortin-3 preproprotein

      See identical proteins and their annotated locations for NP_444277.2

      Status: REVIEWED

      Source sequence(s)
      AL683826, AY026949, BQ776877, BQ777111, BQ778217, CK821206
      Consensus CDS
      CCDS7065.1
      UniProtKB/Swiss-Prot
      Q496H2, Q5SR91, Q969E3
      Related
      ENSP00000369798.3, ENST00000380433.5
      Conserved Domains (1) summary
      pfam00473
      Location:120157
      CRF; Corticotropin-releasing factor family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      5364966..5374692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      5366734..5377963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)