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    RPSA ribosomal protein SA [ Homo sapiens (human) ]

    Gene ID: 3921, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RPSAprovided by HGNC
    Official Full Name
    ribosomal protein SAprovided by HGNC
    Primary source
    HGNC:HGNC:6502
    See related
    Ensembl:ENSG00000168028 MIM:150370; AllianceGenome:HGNC:6502
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SA; LBP; LRP; p40; uS2; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4
    Summary
    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 792.7), lymph node (RPKM 583.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPSA in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (39406720..39412542)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (39419647..39425467)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (39448211..39454033)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14225 Neighboring gene uncharacterized LOC105377644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19707 Neighboring gene solute carrier family 25 member 38 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:39445554-39446346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:39447932-39448723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:39450309-39451100 Neighboring gene uncharacterized LOC107986075 Neighboring gene small nucleolar RNA, H/ACA box 6 Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14229 Neighboring gene NANOG hESC enhancer GRCh37_chr3:39508789-39509471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:39513805-39514612 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:39514613-39515420 Neighboring gene myelin associated oligodendrocyte basic protein Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:39547383-39547882

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Connecting isolated congenital asplenia to the ribosome]. Bolze A. Biol Aujourdhui, 2014. PMID 25840456
    2. Expression of laminin receptor 1 in human placentas from normal and preeclamptic pregnancies and its relationship with the severity of preeclampsia. Kurdoglu M, et al. J Perinat Med, 2011 Jul. PMID 21391874
    3. The first report of RPSA polymorphisms, also called 37/67 kDa LRP/LR gene, in sporadic Creutzfeldt-Jakob disease (CJD). Yun J, et al. BMC Med Genet, 2011 Aug 13. PMID 21838916, Free PMC Article
    4. Conformational switch of a flexible loop in human laminin receptor determines laminin-1 interaction. Di Giovanni C, et al. Eur Biophys J, 2012 Mar. PMID 22290616
    5. Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor. Fujimura Y, et al. PLoS One, 2012. PMID 22666419, Free PMC Article

    See all (362) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Laminin receptor 1 expression in premalignant and malignant squamous lesions of the cervix.
      Title: Laminin receptor 1 expression in premalignant and malignant squamous lesions of the cervix.
    2. Ribosomal protein SA is a common component of neuronal intranuclear inclusions in polyglutamine diseases and Marinesco bodies.
      Title: Ribosomal protein SA is a common component of neuronal intranuclear inclusions in polyglutamine diseases and Marinesco bodies.
    3. LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination.
      Title: LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination.
    4. The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
      Title: The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
    5. AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner.
      Title: AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner.
    6. Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature.
      Title: Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature.
    7. MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA.
      Title: MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA.
    8. Dentate gyrus volume deficit in schizophrenia.
      Title: Dentate gyrus volume deficit in schizophrenia.
    9. Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751.
      Title: Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751.
    10. LRP::FLAG Rescues Cells from Amyloid-beta-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity.
      Title: LRP::FLAG Rescues Cells from Amyloid-β-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity.
    Submit: New GeneRIF Correction See all GeneRIFs (90)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Familial isolated congenital asplenia
    MedGen: C0685889 OMIM: 271400 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, ribosomal protein SA (RPSA), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables laminin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS2
    Names
    37 kDa laminin receptor
    37/67 kDa laminin receptor
    40S ribosomal protein SA
    67 kDa laminin receptor
    colon carcinoma laminin-binding protein
    laminin receptor 1 (67kD, ribosomal protein SA)
    laminin-binding protein precursor p40
    multidrug resistance-associated protein MGr1-Ag

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033234.1 RefSeqGene

      Range
      5008..10830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_735

    mRNA and Protein(s)

    1. NM_001304288.2 → NP_001291217.1  small ribosomal subunit protein uS2 isoform 2

      See identical proteins and their annotated locations for NP_001291217.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is longer compared to isoform 1.
      Source sequence(s)
      BC070263, BC071968, BM999786, X15005
      Consensus CDS
      CCDS77723.1
      UniProtKB/TrEMBL
      A0A0C4DG17, Q96RS2
      Related
      ENSP00000389351.1, ENST00000443003.2
      Conserved Domains (1) summary
      PTZ00254
      Location:1 → 255
      PTZ00254; 40S ribosomal protein SA; Provisional

    2. NM_002295.6 → NP_002286.2  small ribosomal subunit protein uS2 isoform 1

      See identical proteins and their annotated locations for NP_002286.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      BC070263, BC071968, BM999786
      Consensus CDS
      CCDS2686.1
      UniProtKB/Swiss-Prot
      P08865, P11085, P12030, Q16471, Q6IPD1, Q6IPD2, Q6NSD1, Q6NXQ8, Q86VC0
      UniProtKB/TrEMBL
      Q96RS2
      Related
      ENSP00000346067.4, ENST00000301821.11
      Conserved Domains (1) summary
      PTZ00254
      Location:1 → 250
      PTZ00254; 40S ribosomal protein SA; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      39406720..39412542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      39419647..39425467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08865.4 GenPept UniProtKB/Swiss-Prot:P08865

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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