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    MEIG1 meiosis/spermiogenesis associated 1 [ Homo sapiens (human) ]

    Gene ID: 644890, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MEIG1provided by HGNC
    Official Full Name
    meiosis/spermiogenesis associated 1provided by HGNC
    Primary source
    HGNC:HGNC:23429
    See related
    Ensembl:ENSG00000197889 MIM:614174; AllianceGenome:HGNC:23429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPATA39; bA2K17.3
    Summary
    Predicted to be involved in cell differentiation. Predicted to act upstream of or within manchette assembly and protein localization. Predicted to be located in cytosol and manchette. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis (RPKM 4.2) and brain (RPKM 0.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See MEIG1 in Genome Data Viewer
    Location:
    10p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (14954228..14988050)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (14968185..15002020)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15001387..15030049)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene SUV39H2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2164 Neighboring gene SUV39H2 histone lysine methyltransferase Neighboring gene NANOG hESC enhancer GRCh37_chr10:14946352-14947052 Neighboring gene DNA cross-link repair 1C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3087 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:14994732-14995460 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:14995461-14996188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15033655-15034186 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:15034187-15034717 Neighboring gene olfactory receptor family 7 subfamily E member 110 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 26 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 115 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. Teves ME, et al. Andrology, 2013 Jan. PMID 23258628, Free PMC Article
    2. Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding. Khan N, et al. Structure, 2021 Jun 3. PMID 33529594, Free PMC Article
    3. MEIG1 is essential for spermiogenesis in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805151, Free PMC Article
    4. Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility. Gupta N, et al. Andrologia, 2022 Oct. PMID 35768906
    5. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Zhang Z, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15328412, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.
      Title: Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.
    2. Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.
      Title: Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in manchette assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    meiosis expressed gene 1 protein homolog
    Names
    meiosis expressed gene 1 homolog
    spermatogenesis associated 39

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080836.3 → NP_001074305.1  meiosis expressed gene 1 protein homolog

      See identical proteins and their annotated locations for NP_001074305.1

      Status: VALIDATED

      Source sequence(s)
      AA971146, AI694434, AL360083, BG189536
      Consensus CDS
      CCDS31151.1
      UniProtKB/Swiss-Prot
      Q5JSS6
      Related
      ENSP00000384334.1, ENST00000407572.6
      Conserved Domains (1) summary
      pfam15163
      Location:11 → 86
      Meiosis_expr; Meiosis-expressed

    RNA

    1. NR_147060.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL360083, BG189096, BX115809

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      14954228..14988050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448136.1 → XP_024303904.1  meiosis expressed gene 1 protein homolog isoform X1

      Conserved Domains (1) summary
      pfam15163
      Location:42 → 117
      Meiosis_expr; Meiosis-expressed

    2. XM_047425662.1 → XP_047281618.1  meiosis expressed gene 1 protein homolog isoform X2

      UniProtKB/Swiss-Prot
      Q5JSS6
      Related
      ENSP00000367486.1, ENST00000378240.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      14968185..15002020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366617.1 → XP_054222592.1  meiosis expressed gene 1 protein homolog isoform X1

    2. XM_054366618.1 → XP_054222593.1  meiosis expressed gene 1 protein homolog isoform X3

    3. XM_054366619.1 → XP_054222594.1  meiosis expressed gene 1 protein homolog isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_134493.1: Suppressed sequence

      Description
      NR_134493.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JSS6.1 GenPept UniProtKB/Swiss-Prot:Q5JSS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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