Mogs mannosyl-oligosaccharide glucosidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mogsprovided by MGI
Official Full Name: mannosyl-oligosaccharide glucosidaseprovided by MGI
Primary source: MGI:MGI:1929872
See related: Ensembl:ENSMUSG00000030036 AllianceGenome:MGI:1929872
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gcs1; 1810017N02Rik
Summary: Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 54.3), ovary adult (RPKM 52.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83092477..83095883)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83115506..83118902)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased GCS1 expression alleviates fatty acid-induced ER stress and is critical for suppressing ER stress-associated lipogenic gene activation.
Title: p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:546869

Mogs (e-PCR), detects polymorphism
- UniSTS:546869

RH135911 (e-PCR)
- UniSTS:209909

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in oligosaccharide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mannosyl-oligosaccharide glucosidase

Names: ER glu I; endoplasmic reticulum alpha-glucosidase I; glucosidase 1; glycoprotein-processing glucosidase I

NP_065644.2

EC 3.2.1.106

XP_006506487.1

EC 3.2.1.106

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020619.3 → NP_065644.2 mannosyl-oligosaccharide glucosidase

See identical proteins and their annotated locations for NP_065644.2

Status: VALIDATED

Source sequence(s)

BC051949, BY625811

Consensus CDS

CCDS20273.1

UniProtKB/Swiss-Prot

Q80UM7, Q9Z2W5

UniProtKB/TrEMBL

Q3U026, Q3UME9

Related

ENSMUSP00000032114.8, ENSMUST00000032114.8

Conserved Domains (2) summary

pfam03200
Location:349 → 832

Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain

pfam16923
Location:92 → 243

Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

83092477..83095883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506424.3 → XP_006506487.1 mannosyl-oligosaccharide glucosidase isoform X1

Conserved Domains (1) summary

pfam03200
Location:75 → 558

Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain