Alg6 ALG6, alpha-1,3-glucosyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alg6provided by RGD
Official Full Name: ALG6, alpha-1,3-glucosyltransferaseprovided by RGD
Primary source: RGD:1308815
See related: EnsemblRapid:ENSRNOG00000009045 AllianceGenome:RGD:1308815
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 51.9), Kidney (RPKM 51.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (119520415..119606365)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (114404972..114454440)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (118415680..118470634)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligosaccharide-lipid intermediate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide-lipid intermediate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

Names: asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase); asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog; asparagine-linked glycosylation protein 6 homolog; dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase

NP_001028881.1

EC 2.4.1.267

XP_038966196.1

EC 2.4.1.267

XP_038966197.1

EC 2.4.1.267

XP_063144018.1

EC 2.4.1.267

XP_063144019.1

EC 2.4.1.267

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033709.1 → NP_001028881.1 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor

See identical proteins and their annotated locations for NP_001028881.1

Status: PROVISIONAL

Source sequence(s)

BC101850

UniProtKB/Swiss-Prot

Q3T1L5

UniProtKB/TrEMBL

F1LMD6

Related

ENSRNOP00000093347.2, ENSRNOT00000107656.2

Conserved Domains (1) summary

pfam03155
Location:32 → 485

Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

119520415..119606365

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287948.1 → XP_063144018.1 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X1
XM_063287949.1 → XP_063144019.1 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X3

UniProtKB/TrEMBL

A0A8I6AJN8

Related

ENSRNOP00000109337.1, ENSRNOT00000133198.1
XM_039110268.1 → XP_038966196.1 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X2

UniProtKB/TrEMBL

F1LMD6

Related

ENSRNOP00000012052.9, ENSRNOT00000012052.9

Conserved Domains (1) summary

pfam03155
Location:98 → 521

Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
XM_039110269.2 → XP_038966197.1 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

Conserved Domains (1) summary

cl21590
Location:98 → 371

PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase