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    BRE2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850702, updated on 11-Sep-2024

    Summary

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    Official Symbol
    BRE2
    Primary source
    SGD:S000004005
    Locus tag
    YLR015W
    See related
    AllianceGenome:SGD:S000004005; FungiDB:YLR015W; VEuPathDB:YLR015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CPS60
    Summary
    Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 trimethylation; subtelomeric heterochromatin assembly; and telomere maintenance. Part of Set1C/COMPASS complex. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (175227..176744)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Gat3p Neighboring gene Ppr1p Neighboring gene Pml1p Neighboring gene S-methyl-5-thioadenosine phosphorylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRAUCO, a Trithorax-group gene homologue, is required for early embryogenesis in Arabidopsis thaliana. Aquea F, et al. J Exp Bot, 2010 Feb. PMID 20118203, Free PMC Article
    2. A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. South PF, et al. J Biol Chem, 2010 Jan 1. PMID 19897479, Free PMC Article
    3. Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Hsu PL, et al. Cell, 2018 Aug 23. PMID 30100181, Free PMC Article
    4. Global study of holistic morphological effectors in the budding yeast Saccharomyces cerevisiae. Suzuki G, et al. BMC Genomics, 2018 Feb 20. PMID 29458326, Free PMC Article
    5. The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation. Choudhury R, et al. Genes Dev, 2019 May 1. PMID 30842216, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bre2 and Sdc1 are shown to directly interact, and it is shown that the association of this heteromeric complex is needed for proper H3K4 methylation and gene expression to occur.
      Title: A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H3K4 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Set1C/COMPASS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bre2p
    NP_013115.1
    • Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      175227..176744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181902.1 → NP_013115.1  TPA: Bre2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY17, E9PA88, P43132
      UniProtKB/TrEMBL
      B3LSY8, C8ZCY7
      Conserved Domains (1) summary
      cd12872
      Location:101 → 244
      SPRY_Ash2; SPRY domain in Ash2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43132.2

    Gene LinkOut

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