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    TOK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853352, updated on 11-Sep-2024

    Summary

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    Official Symbol
    TOK1
    Primary source
    SGD:S000003629
    Locus tag
    YJL093C
    See related
    AllianceGenome:SGD:S000003629; FungiDB:YJL093C; VEuPathDB:YJL093C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DUK1; YKC1; YPK1
    Summary
    Enables voltage-gated potassium channel activity. Involved in cellular potassium ion homeostasis. Located in plasma membrane. Human ortholog(s) of this gene implicated in Birk-Barel syndrome; migraine with aura; and primary pulmonary hypertension. Orthologous to several human genes including KCNK10 (potassium two pore domain channel subfamily K member 10); KCNK16 (potassium two pore domain channel subfamily K member 16); and KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (254737..256812, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase BCK1 Neighboring gene Kha1p Neighboring gene DNA helicase SRS2 Neighboring gene glucosaminyl-phosphotidylinositol O-acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p. Roller A, et al. Pflugers Arch, 2008 Aug. PMID 18421473
    2. Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity. Johansson I, et al. Biochem J, 2006 Feb 1. PMID 16287426, Free PMC Article
    3. In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance. Roller A, et al. Pflugers Arch, 2005 Nov. PMID 16133265
    4. The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel. Loukin SH, et al. Proc Natl Acad Sci U S A, 2002 Feb 19. PMID 11854493, Free PMC Article
    5. Carboxyl tail prevents yeast K(+) channel closure: proposal of an integrated model of TOK1 gating. Loukin SH, et al. Biophys J, 2002 Feb. PMID 11806920, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the functional consequences of the structural asymmetry associated with leucine and tyrosine mutations in the dual pore motifs of the yeast potassium channel, Tok1p.
      Title: Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p.
    2. results demarcate extracellular domains that are associated with the K+-sensitivity of TOK1
      Title: Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity.
    3. Two negative residues in TOK1, Asp292 and Asp426, near the mouth of the assembled channel, modulate both kinetics and conductance of the channel.
      Title: In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular potassium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tok1p
    NP_012442.1
    • Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      254737..256812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181526.1 → NP_012442.1  TPA: Tok1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012442.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW91, P40310, Q05721
      UniProtKB/TrEMBL
      A6ZPN2, B3LQ20, B5VL82, C7GR21, C8ZBC0, G2WGS5, N1NZT0
      Conserved Domains (1) summary
      pfam07885
      Location:388 → 462
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40310.1

    Gene LinkOut

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