TEN1 Ten1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TEN1
Official Full Name: Ten1p
Primary source: SGD:S000004000
Locus tag: YLR010C
See related: AllianceGenome:SGD:S000004000; FungiDB:YLR010C; VEuPathDB:YLR010C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables single-stranded telomeric DNA binding activity; transcription elongation regulator activity; and translation elongation factor binding activity. Involved in regulation of nucleobase-containing compound metabolic process and telomere maintenance. Part of CST complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TEN1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (167320..167802, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast.
Title: Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast.
Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions.
Title: Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions.
Ten1, Cdc13 and Stn1, were found to physically associate with Spt5. This study proposes that Spt5 represents the target of the Cdc13-Stn1-Ten1 complex in transcription regulation.
Title: The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription.
Data support a model that Stn1 and Ten1 can function in a Cdc13-independent manner and have implications for the function of CST components across eukaryotes.
Title: Interplay between nonsense-mediated mRNA decay and DNA damage response pathways reveals that Stn1 and Ten1 are the key CST telomere-cap components.
Data show that by controlling the timing of Cdc13 and Stn1 phosphorylations, Cdk1 regulates the temporal recruitment of telomerase complexes and Cdc13-Stn1-Ten1 (CST) complexes to the telomeres to facilitate telomere maintenance.
Title: Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication.
Results emphasize that Cdc13 relies on Ten1 to execute its essential function, but leave open the possibility that Ten1 has a Cdc13-independent role in DNA replication.
Title: TEN1 is essential for CDC13-mediated telomere capping.
Ten1 protein interacts with Cdc13 protein to promote its telemeric TG(1-3) DNA-binding activity.
Title: Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation.
Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates.
Title: RPA-like proteins mediate yeast telomere function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables single-stranded telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription elongation factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables translation elongation factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere capping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomerase	IGI Inferred from Genetic Interaction more info	PubMed
involved_in telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CST complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ten1p

NP_013110.1

Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex