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    MMP1 S-methylmethionine permease MMP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850665, updated on 1-Aug-2024

    Summary

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    Gene symbol
    MMP1
    Gene description
    S-methylmethionine permease MMP1
    Primary source
    FungiDB:YLL061W
    Locus tag
    YLL061W
    See related
    SGD:S000003984; AllianceGenome:SGD:S000003984; VEuPathDB:YLL061W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables S-methylmethionine transmembrane transporter activity. Involved in S-methylmethionine transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria; lysinuric protein intolerance; and retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MMP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (17956..19707)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene acetyltransferase Neighboring gene S-adenosylmethionine-homocysteine S-methyltransferase MHT1 Neighboring gene glutathione transferase GTT2 Neighboring gene cystathionine gamma-synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae. Rouillon A, et al. J Biol Chem, 1999 Oct 1. PMID 10497160
    2. Functional Analysis of six novel ORFs on the left arm of Chromosome XII of Saccharomyces cerevisiae reveals three of them responding to S-starvation. Zhang N, et al. Yeast, 2001 Mar 15. PMID 11223942
    3. New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome. Conan P, et al. Front Neurosci, 2022. PMID 36711154, Free PMC Article
    4. The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance. Avci D, et al. Mol Cell, 2014 Dec 4. PMID 25454947
    5. A Plasma Membrane Association Module in Yeast Amino Acid Transporters. Popov-Čeleketić D, et al. J Biol Chem, 2016 Jul 29. PMID 27226538, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-methylmethionine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-methylmethionine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S-methylmethionine permease MMP1
    NP_013039.1
    • High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      17956..19707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181881.1 → NP_013039.1  TPA: S-methylmethionine permease MMP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013039.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXU8, Q12372
      UniProtKB/TrEMBL
      A7A0K0, B3LTB8, B5VMP5, C7GND6
      Conserved Domains (1) summary
      TIGR00913
      Location:70 → 547
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12372.1

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