MDV1 Mdv1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Gene symbol: MDV1
Gene description: Mdv1p
Primary source: FungiDB:YJL112W
Locus tag: YJL112W
See related: SGD:S000003648; AllianceGenome:SGD:S000003648; VEuPathDB:YJL112W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GAG3; NET2
Summary: Enables ubiquitin binding activity. Involved in mitochondrial fission; mitochondrial genome maintenance; and peroxisome fission. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See MDV1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (205305..207449)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for association with the mitochondrial adaptor Mdv1
Title: A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment.
in addition to dimerization, the unusually long Mdv1 coiled coil serves a scaffolding function to stabilize the Mdv1-Fis1 complex.
Title: Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (Mdv1) coiled coil.
Although deletion of Ty3 spacer domain dramatically reduced retrotransposition, significant Gag3 processing and cDNA synthesis occurred.
Title: The TY3 Gag3 spacer controls intracellular condensation and uncoating.
Mdv1 CC lies parallel to the bilayer with N termini at opposite ends bound to Fis1 and C-terminal beta-propeller domains (Dnm1-binding sites) extending into the cytoplasm
Title: Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.
Mdv1 played a postmitochondrial targeting role in division by interacting & coassembling with the GTP-bound form of Dnm1; this regulated interaction nucleated & promoted self-assembly of Dnm1 into helical structures which drive membrane scission
Title: Mechanistic analysis of a dynamin effector.
findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p; association of Caf4p and Mdv1p with peroxisomes relies on Fis1p
Title: Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p.
the concave surface of the Fis1 tetratricopeptide repeat-like domain is evolutionarily conserved to bind the dynamin-like GTPase Dnm1 and not Mdv1 as previously predicted
Title: Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm.
Dnm1p dimers are initially recruited to the membrane via interaction with Mdv1p.Fis1p complexes
Title: Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1.
the N terminus of Fis1 is a prerequisite to recruit Mdv1 to facilitate mitochondrial fission
Title: Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.
dynamic interactions between Mdv1 and Dnm1 play a key role in division by regulating Dnm1 self-assembly
Title: Mdv1 interacts with assembled dnm1 to promote mitochondrial division.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial fission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IPI Inferred from Physical Interaction more info	PubMed
involved_in mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Mdv1p

NP_012423.1

Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

205305..207449

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181545.2 → NP_012423.1 TPA: Mdv1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012423.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZQL5, D6VW72, P47025

UniProtKB/TrEMBL

G2WGQ7, N1P420

Conserved Domains (3) summary

cd00200
Location:397 → 713

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:402 → 439

7WD40; WD40 repeat [structural motif]

pfam11542
Location:123 → 171

Mdv1; Mitochondrial division protein 1